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TNK2 tyrosine kinase non receptor 2 [ Gallus gallus (chicken) ]

Gene ID: 431014, updated on 3-Apr-2024

Summary

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Symbol
TNK2provided by CGNC
Full Name
tyrosine kinase non receptor 2provided by CGNC
Primary source
CGNC:26882
See related
Ensembl:ENSGALG00010015146
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (14647452..14667074)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (14443420..14463005)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417078 Neighboring gene transferrin receptor Neighboring gene mucin 4, cell surface associated Neighboring gene mucin 4 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
activated CDC42 kinase 1
XP_004943402.2
XP_015146941.2
XP_015146942.2
XP_015146943.2
XP_015146944.1
XP_015146945.1
XP_015146947.1
XP_025009316.2
XP_040534575.1
XP_040534576.1
XP_040534578.1
XP_040534579.1
XP_040534580.1
XP_040534581.1
XP_040534582.1
XP_040534584.1
XP_046754440.1
XP_046754441.1
XP_046780000.1
XP_046780001.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    14647452..14667074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015291459.4 → XP_015146945.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A8V0YK08
    Related
    ENSGALP00010021268.1, ENSGALT00010036519.1
    Conserved Domains (7) summary
    cd09539
    Location:45 → 90
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:413 → 461
    SH3; Src homology 3 domains
    cd14274
    Location:1021 → 1065
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1052 → 1091
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:150 → 407
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:469 → 534
    GTPase_binding; GTPase binding
    pfam11555
    Location:844 → 913
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  2. XM_046898485.1 → XP_046754441.1  activated CDC42 kinase 1 isoform X9

    Related
    ENSGALP00010021258.1, ENSGALT00010036509.1

  3. XM_046898484.1 → XP_046754440.1  activated CDC42 kinase 1 isoform X2

  4. XM_015291461.4 → XP_015146947.1  activated CDC42 kinase 1 isoform X9

    UniProtKB/TrEMBL
    A0A3Q2UHM8
    Conserved Domains (7) summary
    cd09539
    Location:22 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:390 → 438
    SH3; Src homology 3 domains
    cd14274
    Location:998 → 1042
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1029 → 1068
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:127 → 384
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:446 → 511
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 890
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  5. XM_004943345.5 → XP_004943402.2  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YRC9, A0A8V0YY50
    Related
    ENSGALP00010021250.1, ENSGALT00010036497.1
    Conserved Domains (5) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:512 → 560
    SH3; Src homology 3 domains
    cd14274
    Location:1120 → 1164
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1151 → 1190
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  6. XM_015291455.4 → XP_015146941.2  activated CDC42 kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (5) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:512 → 560
    SH3; Src homology 3 domains
    cd14274
    Location:1095 → 1139
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1126 → 1165
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  7. XM_015291456.4 → XP_015146942.2  activated CDC42 kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YJZ3, A0A8V0YY50
    Related
    ENSGALP00010021253.1, ENSGALT00010036503.1
    Conserved Domains (6) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:512 → 560
    SH3; Src homology 3 domains
    PHA03247
    Location:587 → 1040
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1080 → 1124
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1111 → 1150
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  8. XM_015291457.4 → XP_015146943.2  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YT31, A0A8V0YY50
    Related
    ENSGALP00010021256.1, ENSGALT00010036507.1
    Conserved Domains (4) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:1055 → 1099
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1086 → 1125
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  9. XM_025153548.3 → XP_025009316.2  activated CDC42 kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (4) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:1015 → 1059
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1046 → 1085
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  10. XM_015291458.4 → XP_015146944.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2UHM8, A0A8V0YRC4
    Related
    ENSGALP00010021245.1, ENSGALT00010036490.1
    Conserved Domains (7) summary
    cd09539
    Location:48 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:416 → 464
    SH3; Src homology 3 domains
    cd14274
    Location:1024 → 1068
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1055 → 1094
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:153 → 410
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:472 → 537
    GTPase_binding; GTPase binding
    pfam11555
    Location:847 → 916
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    14443420..14463005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040678647.2 → XP_040534581.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A8V0YK08
    Conserved Domains (7) summary
    cd09539
    Location:45 → 90
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:413 → 461
    SH3; Src homology 3 domains
    cd14274
    Location:1021 → 1065
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1052 → 1091
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:150 → 407
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:469 → 534
    GTPase_binding; GTPase binding
    pfam11555
    Location:844 → 913
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  2. XM_046924045.1 → XP_046780001.1  activated CDC42 kinase 1 isoform X9

  3. XM_046924044.1 → XP_046780000.1  activated CDC42 kinase 1 isoform X2

  4. XM_040678650.2 → XP_040534584.1  activated CDC42 kinase 1 isoform X9

    UniProtKB/TrEMBL
    A0A3Q2UHM8
    Conserved Domains (7) summary
    cd09539
    Location:22 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:390 → 438
    SH3; Src homology 3 domains
    cd14274
    Location:998 → 1042
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1029 → 1068
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:127 → 384
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:446 → 511
    GTPase_binding; GTPase binding
    pfam11555
    Location:821 → 890
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  5. XM_040678641.2 → XP_040534575.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (5) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:512 → 560
    SH3; Src homology 3 domains
    cd14274
    Location:1120 → 1164
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1151 → 1190
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  6. XM_040678642.2 → XP_040534576.1  activated CDC42 kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (5) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:512 → 560
    SH3; Src homology 3 domains
    cd14274
    Location:1095 → 1139
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1126 → 1165
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  7. XM_040678644.2 → XP_040534578.1  activated CDC42 kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (6) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:512 → 560
    SH3; Src homology 3 domains
    PHA03247
    Location:587 → 1040
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1080 → 1124
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1111 → 1150
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  8. XM_040678645.2 → XP_040534579.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (4) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14274
    Location:1055 → 1099
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1086 → 1125
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  9. XM_040678648.2 → XP_040534582.1  activated CDC42 kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A8V0YY50
    Conserved Domains (5) summary
    cd09539
    Location:144 → 189
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:546 → 975
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1015 → 1059
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1046 → 1085
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:249 → 506
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  10. XM_040678646.2 → XP_040534580.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2UHM8, A0A8V0YRC4
    Conserved Domains (7) summary
    cd09539
    Location:48 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:416 → 464
    SH3; Src homology 3 domains
    cd14274
    Location:1024 → 1068
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1055 → 1094
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:153 → 410
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:472 → 537
    GTPase_binding; GTPase binding
    pfam11555
    Location:847 → 916
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
Nucleotide Protein
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