HTR2C 5-hydroxytryptamine receptor 2C [Gallus gallus (chicken)] - Gene

Summary

Symbol: HTR2Cprovided by CGNC
Full Name: 5-hydroxytryptamine receptor 2Cprovided by CGNC
Primary source: CGNC:4369
See related: Ensembl:ENSGALG00010018615
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (2543106..2783034)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (2579473..2819319)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced HTR2C gene expression (151.1-fold) that was associated with high feather damage indicated that the right cerebrum might be the critical region for HTR2C to participate in the regulation of receiving feather pecking behavior.
Title: Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers.
A role of the gene for the serotonin receptor 2C (HTR2C) on chromosome 4 was found. This supports existing evidence of a prominent involvement of the serotonergic system in the modulation of this behavioural disorder in laying hens.
Title: Across-line SNP association study for direct and associative effects on feather damage in laying hens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables neurotransmitter receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info	PubMed
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2C

Names: 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318421.1 → NP_001305350.1 5-hydroxytryptamine receptor 2C precursor

Status: PROVISIONAL

Source sequence(s)

HQ438966

UniProtKB/TrEMBL

F1N989, F5ANP2

Conserved Domains (1) summary

cd15305
Location:66 → 397

7tmA_5-HT2C; serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2543106..2783034

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046940307.1 → XP_046796263.1 5-hydroxytryptamine receptor 2C isoform X2
XM_004940650.5 → XP_004940707.1 5-hydroxytryptamine receptor 2C isoform X1

See identical proteins and their annotated locations for XP_004940707.1

UniProtKB/TrEMBL

F1N989, F5ANP2

Related

ENSGALP00010026916.1, ENSGALT00010045052.1

Conserved Domains (1) summary

cd15305
Location:66 → 397

7tmA_5-HT2C; serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_004940651.5 → XP_004940708.1 5-hydroxytryptamine receptor 2C isoform X2

See identical proteins and their annotated locations for XP_004940708.1

Conserved Domains (2) summary

cd14964
Location:67 → 93

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:66 → 330

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_046940304.1 → XP_046796260.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2
XM_046940308.1 → XP_046796264.1 5-hydroxytryptamine receptor 2C isoform X2
XM_046940303.1 → XP_046796259.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2
XM_046940306.1 → XP_046796262.1 5-hydroxytryptamine receptor 2C isoform X2
XM_040699098.1 → XP_040555032.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2

Conserved Domains (1) summary

cd15305
Location:66 → 397

7tmA_5-HT2C; serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_040699099.1 → XP_040555033.1 5-hydroxytryptamine receptor 2C isoform X2

Conserved Domains (2) summary

cd14964
Location:67 → 93

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:66 → 330

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_046940309.1 → XP_046796265.1 5-hydroxytryptamine receptor 2C isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

2579473..2819319

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046916513.1 → XP_046772469.1 5-hydroxytryptamine receptor 2C isoform X2
XM_046916507.1 → XP_046772463.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2
XM_046916511.1 → XP_046772467.1 5-hydroxytryptamine receptor 2C isoform X2
XM_046916510.1 → XP_046772466.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2
XM_046916514.1 → XP_046772470.1 5-hydroxytryptamine receptor 2C isoform X2
XM_046916508.1 → XP_046772464.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2
XM_046916512.1 → XP_046772468.1 5-hydroxytryptamine receptor 2C isoform X2
XM_046916509.1 → XP_046772465.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

F1N989, F5ANP2
XM_046916515.1 → XP_046772471.1 5-hydroxytryptamine receptor 2C isoform X2
XM_046916516.1 → XP_046772472.1 5-hydroxytryptamine receptor 2C isoform X3