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SMC1 Structural maintenance of chromosomes 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42853, updated on 10-May-2024

Summary

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Official Symbol
SMC1provided by FlyBase
Official Full Name
Structural maintenance of chromosomes 1provided by FlyBase
Primary source
FLYBASE:FBgn0040283
Locus tag
Dmel_CG6057
See related
AllianceGenome:FB:FBgn0040283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF56231; CG6057; Dmel\CG6057; DmSMC1; dSMC1; smc1; Smc1
Summary
Enables chromatin binding activity. Involved in negative regulation of gene expression and nervous system development. Located in nucleus; polytene chromosome; and transcriptionally active chromatin. Part of cohesin complex. Colocalizes with chromosome. Is expressed in germarium; organism; and spermatocyte. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2 and developmental and epileptic encephalopathy. Orthologous to human SMC1A (structural maintenance of chromosomes 1A) and SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
95D11-95D11; 3-82 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24058287..24062815)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19884009..19888537)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44097 Neighboring gene Phosphatidylserine decarboxylase Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 68 Neighboring gene eukaryotic translation initiation factor 4E homologous protein Neighboring gene Syntaxin 1A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Review: SMCs in the world of chromosome biology- from prokaryotes to higher eukaryotes. Cobbe N, et al. J Struct Biol, 2000 Apr. PMID 10806064
  2. Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced. Subramanian VV, et al. PLoS Genet, 2008 Nov. PMID 19008956, Free PMC Article
  3. Increased levels of superoxide dismutase suppress meiotic segregation errors in aging oocytes. Perkins AT, et al. Chromosoma, 2019 Sep. PMID 31037468, Free PMC Article
  4. Couples, pairs, and clusters: mechanisms and implications of centromere associations in meiosis. Obeso D, et al. Chromosoma, 2014 Mar. PMID 24126501, Free PMC Article
  5. Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size. Phan A, et al. Neuron, 2019 Jan 2. PMID 30503644, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data indicate that the initial meiotic pairing of homologs is not sufficient to yield synapsis exclusively between homologs and provide a model in which meiotic homolog pairing must be stabilized by centromeric SMC1 to ensure proper synapsis
    Title: Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.
  2. SOLO and SMC1 are both enriched on centromeres throughout prophase I, co-align along the lateral elements of SCs and reciprocally co-immunoprecipitate from ovarian protein extracts.
    Title: The cohesion protein SOLO associates with SMC1 and is required for synapsis, recombination, homolog bias and cohesion and pairing of centromeres in Drosophila Meiosis.
  3. the localization patterns of SOLO and SMC1 indicate that they function together to maintain sister chromatid cohesion in Drosophila meiosis
    Title: SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster.
  4. Meiotic nondisjunction was increased in aged Drosophila oocytes when the cohesin protein SMC1 is reduced.
    Title: Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced.
  5. Two cohesin subunits (SMC1 and SA) are essential for axon pruning.
    Title: piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cohesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cohesin complex IEA
Inferred from Electronic Annotation
more info
  
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
structural maintenance of chromosomes 1
Names
CG6057-PA
SMC1-PA
Smc1 cohesin subunit
cohesin
cohesin complex subunit SMC1
cohesin subunit SMC1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24058287..24062815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142954.4 → NP_651211.2  structural maintenance of chromosomes 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651211.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N6I4, Q9VCD8
    Related
    FBpp0083926
    Conserved Domains (4) summary
    cd03275
    Location:27 → 171
    ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins
    smart00968
    Location:535 → 653
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:26 → 1216
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15771
    Location:697 → 810
    DUF4700; Domain of unknown function (DUF4700)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N6I4 Q9N6I4
Q9VCD8 Q9VCD8

Gene LinkOut

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