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KAT2B lysine acetyltransferase 2B [ Gallus gallus (chicken) ]

Gene ID: 428441, updated on 3-Apr-2024

Summary

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Symbol
KAT2Bprovided by CGNC
Full Name
lysine acetyltransferase 2Bprovided by CGNC
Primary source
CGNC:8571
See related
Ensembl:ENSGALG00010001778
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PCAF
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (35753320..35795521)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (35802778..35844977)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 7-like Neighboring gene EF-hand domain family member B Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C like domain containing 1 Neighboring gene shugoshin 1 Neighboring gene zinc finger protein 385D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells. Kikuchi H, et al. Microbiol Immunol, 2015 Apr. PMID 25644304
  2. GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk. Kikuchi H, et al. Biochem Biophys Res Commun, 2011 Feb 25. PMID 21281601
  3. Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells. Kikuchi H, et al. FEBS Lett, 2014 May 2. PMID 24657615
  4. GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. Kikuchi H, et al. Gene, 2005 Feb 28. PMID 15715965
  5. Recruitment of histone modifications by USF proteins at a vertebrate barrier element. West AG, et al. Mol Cell, 2004 Nov 5. PMID 15525517

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCAF suppressed secretory immunoglobulin synthesis in immature B cells.
    Title: Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells.
  2. GCN5 binds to the 5'-flanking region of the chicken PRKCQ gene and acetylates histone H3, and EBF1 binds to the 5'-flanking region of the gene surrounding putative EBF1 binding motifs.
    Title: Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.
  3. These results suggest that GCN5 takes part in transcriptional regulations of the Syk and Btk genes, and plays a key role in epigenetic regulation of PI3K/Akt survival pathway in B cells exposed to reactive oxygen species such as H(2)O(2).
    Title: GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase KAT2B
Names
K(lysine) acetyltransferase 2B
p300/CBP-associated factor
XP_015137289.3
XP_040519860.1
XP_046768259.1
XP_046768260.1
XP_046768261.1
XP_046793599.1
XP_046793601.1
XP_046793603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    35753320..35795521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046937645.1 → XP_046793601.1  histone acetyltransferase KAT2B isoform X3

  2. XM_015281803.4 → XP_015137289.3  histone acetyltransferase KAT2B isoform X2

    UniProtKB/TrEMBL
    A0A8V0X6X9, Q90ZI1
    Related
    ENSGALP00010002359.1, ENSGALT00010004061.1
    Conserved Domains (2) summary
    cd05509
    Location:703 → 802
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:463 → 796
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

  3. XM_046937647.1 → XP_046793603.1  histone acetyltransferase KAT2B isoform X3

  4. XM_046937643.1 → XP_046793599.1  histone acetyltransferase KAT2B isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    35802778..35844977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046912304.1 → XP_046768260.1  histone acetyltransferase KAT2B isoform X3

  2. XM_040663926.2 → XP_040519860.1  histone acetyltransferase KAT2B isoform X2

    UniProtKB/TrEMBL
    Q90ZI1
    Conserved Domains (2) summary
    cd05509
    Location:703 → 802
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:463 → 796
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

  3. XM_046912305.1 → XP_046768261.1  histone acetyltransferase KAT2B isoform X3

  4. XM_046912303.1 → XP_046768259.1  histone acetyltransferase KAT2B isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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