DRD2 dopamine receptor D2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: DRD2provided by CGNC
Full Name: dopamine receptor D2provided by CGNC
Primary source: CGNC:5893
See related: Ensembl:ENSGALG00010024922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: D(2)
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	24	NC_052555.1 (5767329..5790215)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	24	NC_052596.1 (5727618..5750561)

Chromosome 24 - NC_052555.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hyperphagia observed when central CB1 receptors are stimulated is dependent on stimulation of D2 DAergic receptors, whilst the hyperphagia induced by CB2 ECB receptors is attenuated when the DAergic system is activated through D2 receptors in layer hens.
Title: Consequence of dopamine D2 receptor blockade on the hyperphagic effect induced by cannabinoid CB1 and CB2 receptors in layers.
cDRD2 and cDRD4 are widely expressed in chicken tissues with abundant expression noted in anterior pituitary
Title: Dopamine D2-like receptors (DRD2 and DRD4) in chickens: Tissue distribution, functional analysis, and their involvement in dopamine inhibition of pituitary prolactin expression.
These findings suggested that the DRD2 gene should be included in future genetic studies of chicken broodiness and 2 SNP of A-16105G and T+619C might be markers for breeding against broodiness.
Title: The dopamine D2 receptor gene polymorphisms associated with chicken broodiness.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: D(2) dopamine receptor

Names: dopamine receptor 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113290.2 → NP_001106761.1 D(2) dopamine receptor

See identical proteins and their annotated locations for NP_001106761.1

Status: VALIDATED

Source sequence(s)

JAENSK010000341

UniProtKB/TrEMBL

A0A077K956, A9YZQ5, F1NP41

Related

ENSGALP00010037640.1, ENSGALT00010060883.1

Conserved Domains (1) summary

cd15309
Location:32 → 431

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors