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SKI SKI proto-oncogene [ Gallus gallus (chicken) ]

Gene ID: 428181, updated on 3-Apr-2024

Summary

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Symbol
SKIprovided by CGNC
Full Name
SKI proto-oncogeneprovided by CGNC
Primary source
CGNC:838
See related
Ensembl:ENSGALG00010020038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
C-SKI; v-ski
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (1666995..1766806, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (1698472..1798275, complement)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054921 Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene uncharacterized LOC121107373 Neighboring gene microRNA 1635 Neighboring gene uncharacterized LOC107049018 Neighboring gene protein kinase C zeta Neighboring gene cilia and flagella associated protein 74

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of three distinct cDNAs for the chicken c-ski gene. Sutrave P, et al. Mol Cell Biol, 1989 Sep. PMID 2779576, Free PMC Article
  2. Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism. Ye F, et al. J Biol Chem, 2011 Nov 18. PMID 21917928, Free PMC Article
  3. Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. Cohen SB, et al. Nucleic Acids Res, 1999 Feb 15. PMID 9927733, Free PMC Article
  4. Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. Kim KO, et al. J Cell Biochem, 2012 Jun. PMID 22461172, Free PMC Article
  5. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. Dahl R, et al. Oncogene, 1998 Mar 26. PMID 9569025

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that inhibition of TGF-beta signaling by Ski, which involves its association with phospho-Smad3 and recruitment of HDAC4 and 5, leads to accelerated chondrocyte differentiation
    Title: Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.
  2. Peroxisome proliferator-activated receptor gamma (PPARgamma) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.
    Title: Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ski oncogene
Names
proto-oncogene c-Ski
v-ski avian sarcoma viral oncogene homolog
v-ski sarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039318.2 → NP_001034407.2  ski oncogene

    Status: VALIDATED

    Source sequence(s)
    BU423975, JAENSK010000329, M28517
    UniProtKB/Swiss-Prot
    P49140
    UniProtKB/TrEMBL
    E1BSJ7
    Related
    ENSGALP00010028545.1, ENSGALT00010048415.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1666995..1766806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046903176.1 → XP_046759132.1  ski oncogene isoform X1

    UniProtKB/TrEMBL
    E1BSJ7

  2. XM_015296939.4 → XP_015152425.1  ski oncogene isoform X4

    UniProtKB/Swiss-Prot
    P49140
    UniProtKB/TrEMBL
    A0A8V0ZCW9
    Related
    ENSGALP00010028542.1, ENSGALT00010048409.1
    Conserved Domains (3) summary
    pfam02437
    Location:75 → 173
    Ski_Sno; SKI/SNO/DAC family
    pfam08782
    Location:199 → 292
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam13863
    Location:556 → 688
    DUF4200; Domain of unknown function (DUF4200)

  3. XM_025142547.3 → XP_024998315.1  ski oncogene isoform X3

    UniProtKB/Swiss-Prot
    P49140
    Conserved Domains (5) summary
    smart01046
    Location:198 → 293
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam02437
    Location:75 → 173
    Ski_Sno; SKI/SNO/DAC family
    pfam03730
    Location:279 → 317
    Ku_C; Ku70/Ku80 C-terminal arm
    cl25732
    Location:523 → 694
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:396 → 533
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  4. XM_015296936.4 → XP_015152422.1  ski oncogene isoform X2

    UniProtKB/Swiss-Prot
    P49140
    UniProtKB/TrEMBL
    A0A8V0ZCW4
    Related
    ENSGALP00010028537.1, ENSGALT00010048401.1
    Conserved Domains (3) summary
    pfam02437
    Location:75 → 173
    Ski_Sno; SKI/SNO/DAC family
    pfam08782
    Location:199 → 292
    c-SKI_SMAD_bind; c-SKI Smad4 binding domain
    pfam13863
    Location:593 → 725
    DUF4200; Domain of unknown function (DUF4200)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1698472..1798275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931361.1 → XP_046787317.1  ski oncogene isoform X1

    UniProtKB/TrEMBL
    E1BSJ7

  2. XM_046931364.1 → XP_046787320.1  ski oncogene isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZCW9

  3. XM_046931363.1 → XP_046787319.1  ski oncogene isoform X3

  4. XM_046931362.1 → XP_046787318.1  ski oncogene isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZCW4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49140.1 GenPept UniProtKB/Swiss-Prot:P49140

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