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PolE1 DNA polymerase epsilon subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42758, updated on 27-Mar-2024

Summary

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Official Symbol
PolE1provided by FlyBase
Official Full Name
DNA polymerase epsilon subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0264326
Locus tag
Dmel_CG6768
See related
AllianceGenome:FB:FBgn0264326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6768; BAB17608; CG6768; Dmel\CG6768; DNA pol epsilon; DNApol-epsilon; DNApol-epsilon255; dpolepsilon; dpolepsilon255; dpolepsilonp255; l(3)pl10; l(3)pl10R; pl[10]; pol-epsilon; Polepsilon; Polepsilon255; Polepsilon255KDa
Summary
Enables 3'-5'-exodeoxyribonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication proofreading; DNA synthesis involved in DNA replication; and endomitotic cell cycle. Located in nucleus. Part of epsilon DNA polymerase complex. Is expressed in embryonic/larval Malpighian tubule; embryonic/larval salivary gland; gamete; and larval tagma. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
94E13-94E13; 3-78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23348128..23355163)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19173850..19180885)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene big bubble 8 Neighboring gene pointed Neighboring gene long non-coding RNA:CR46090 Neighboring gene ATP synthase, coupling factor 6 Neighboring gene Secretory 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA polymerase epsilon from Drosophila melanogaster. Aoyagi N, et al. Biochem Biophys Res Commun, 1997 Jan 13. PMID 9016770
  2. Subunit protein-affinity isolation of Drosophila DNA polymerase catalytic subunit. Oshige M, et al. Protein Expr Purif, 2004 Jun. PMID 15135399
  3. Molecular cloning and expression during development of the Drosophila gene for the catalytic subunit of DNA polymerase epsilon. Oshige M, et al. Gene, 2000 Oct 3. PMID 11054539
  4. The hsromega(05241) allele of the noncoding hsromega gene of Drosophila melanogaster is not responsible for male sterility as reported earlier. Akanksha, et al. J Genet, 2008 Apr. PMID 18560179
  5. Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster. Ruike T, et al. FEBS J, 2006 Nov. PMID 17087725

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminal catalytic domain of the DNA polymerase epsilon p255 subunit plays role in the G1-S transition and/or S-phase progression of the mitotic cycle.
    Title: Differential requirement for the N-terminal catalytic domain of the DNA polymerase ε p255 subunit in the mitotic cell cycle and the endocycle.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication proofreading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA synthesis involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endomitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of epsilon DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of epsilon DNA polymerase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon subunit 1
Names
CG6768-PA
DNA polymerase epsilon
DNA polymerase epsilon 255kD subunit
DNApol-epsilon
DNApolymarase E
PolE1-PA
lethal (3) pl10
pol.epsilon catalytic subunit
NP_524462.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23348128..23355163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079738.3 → NP_524462.2  DNA polymerase epsilon subunit 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524462.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95R46, Q9VCN1
    UniProtKB/TrEMBL
    G3M399
    Related
    FBpp0083800
    Conserved Domains (3) summary
    cd05779
    Location:266 → 469
    DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
    cd05535
    Location:529 → 1154
    POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
    pfam08490
    Location:1529 → 1930
    DUF1744; Domain of unknown function (DUF1744)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GV40 Q9GV40
Q9VCN1.3 Q9VCN1

Gene LinkOut

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