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CEBPA CCAAT/enhancer binding protein alpha [ Gallus gallus (chicken) ]

Gene ID: 427549, updated on 5-Mar-2024

Summary

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Symbol
CEBPAprovided by CGNC
Full Name
CCAAT/enhancer binding protein alphaprovided by CGNC
Primary source
CGNC:66533
See related
Ensembl:ENSGALG00010025039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
cC/EBP
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
1
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (9940192..9941462, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (10284403..10285673, complement)

Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054294 Neighboring gene uncharacterized LOC107054293 Neighboring gene solute carrier family 7 member 10 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC107054292 Neighboring gene CCAAT/enhancer binding protein gamma Neighboring gene peptidase D Neighboring gene carbohydrate sulfotransferase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Folate supplementation modifies CCAAT/enhancer-binding protein α methylation to mediate differentiation of preadipocytes in chickens. Yu X, et al. Poult Sci, 2014 Oct. PMID 25037819
  2. The chicken CCAAT/enhancer binding protein alpha gene. Cloning, characterisation and tissue distribution. Calkhoven CF, et al. Gene, 1997 Sep 1. PMID 9322761
  3. c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family [corrected]. Calkhoven CF, et al. Nucleic Acids Res, 1992 Aug 11. PMID 1508696, Free PMC Article
  4. CpG site DNA methylation of the CCAAT/enhancer-binding protein, alpha promoter in chicken lines divergently selected for fatness. Gao Y, et al. Anim Genet, 2015 Aug. PMID 26156393
  5. Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α. Yang Q, et al. FEBS J, 2014 Mar. PMID 24418194

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CEBPA promoter is methylated in adipose tissue and may regulate chicken early adipose development
    Title: CpG site DNA methylation of the CCAAT/enhancer-binding protein, alpha promoter in chicken lines divergently selected for fatness.
  2. Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase.
    Title: Folate supplementation modifies CCAAT/enhancer-binding protein α methylation to mediate differentiation of preadipocytes in chickens.
  3. The results of overexpressing C/EBPalpha and HNF4alpha in cultured cells confirmed that both C/EBPalpha and HNF4alpha contribute significantly to sustaining a high level of CYP2D49 transcription.
    Title: Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α.
  4. CEBPA involved in lipid metabolism in Beijing-You chickens.
    Title: Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens.
  5. The result showed C-EBP alpha was sufficient to trigger the adipogenic program in chicken embryo fibroblasts, as demonstrated by accumulation of cytoplasmic lipid droplets and expression of the adipocyte marker gene.
    Title: Transdifferentiation of fibroblasts into adipocyte-like cells by chicken adipogenic transcription factors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CCAAT/enhancer-binding protein alpha
Names
CCAAT/enhancer binding protein (C/EBP), alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031459.2 → NP_001026630.1  CCAAT/enhancer-binding protein alpha

    See identical proteins and their annotated locations for NP_001026630.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000248
    UniProtKB/TrEMBL
    Q90582, R4GLL1
    Related
    ENSGALP00010037816.1, ENSGALT00010061123.1
    Conserved Domains (1) summary
    cd14711
    Location:246 → 306
    bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9940192..9941462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10284403..10285673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.