TLE1 transducin like enhancer of split 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TLE1provided by CGNC
Full Name: transducin like enhancer of split 1provided by CGNC
Primary source: CGNC:9545
See related: Ensembl:ENSGALG00010015766
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human all
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Genomic context

Location:: chromosome: Z

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (39801446..39873047, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (39801446..39873047, complement)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLE is important to promote the formation of the p3 domain and subsequent generation of V3 interneurons.
Title: Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression.

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transducin-like enhancer protein 1

Names: transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

39801446..39873047 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015280363.4 → XP_015135849.1 transducin-like enhancer protein 1 isoform X4

UniProtKB/TrEMBL

A0A8V0YT62

Related

ENSGALP00010021907.1, ENSGALT00010037973.1

Conserved Domains (4) summary

PHA03247
Location:318 → 475

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_003643035.6 → XP_003643083.1 transducin-like enhancer protein 1 isoform X3

UniProtKB/TrEMBL

A0A8V0YT62

Related

ENSGALP00010021904.1, ENSGALT00010037964.1

Conserved Domains (4) summary

PHA03247
Location:319 → 476

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:483 → 767

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:487 → 526

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_015280362.4 → XP_015135848.1 transducin-like enhancer protein 1 isoform X2

UniProtKB/TrEMBL

A0A8V0YT62

Related

ENSGALP00010021903.1, ENSGALT00010037963.1

Conserved Domains (4) summary

COG2319
Location:485 → 777

WD40; WD40 repeat [General function prediction only]

cd00200
Location:492 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:1 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]
XM_004949181.5 → XP_004949238.1 transducin-like enhancer protein 1 isoform X1

UniProtKB/TrEMBL

A0A1D5P5C3, A0A8V0YT62

Related

ENSGALP00010021908.1, ENSGALT00010037976.1

Conserved Domains (4) summary

PHA03247
Location:329 → 486

PHA03247; large tegument protein UL36; Provisional

cd00200
Location:493 → 777

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:497 → 536

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_015280364.3 → XP_015135850.1 transducin-like enhancer protein 1 isoform X5

UniProtKB/TrEMBL

A0A1D5PGR2

Related

ENSGALP00010021900.1, ENSGALT00010037955.1

Conserved Domains (4) summary

COG2319
Location:411 → 703

WD40; WD40 repeat [General function prediction only]

cd00200
Location:418 → 702

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:2 → 68

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:422 → 461

7WD40; WD40 repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

39801446..39873047 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046936734.1 → XP_046792690.1 transducin-like enhancer protein 1 isoform X4
XM_046936733.1 → XP_046792689.1 transducin-like enhancer protein 1 isoform X3
XM_046936732.1 → XP_046792688.1 transducin-like enhancer protein 1 isoform X2
XM_046936731.1 → XP_046792687.1 transducin-like enhancer protein 1 isoform X1

UniProtKB/TrEMBL

A0A1D5P5C3
XM_046936735.1 → XP_046792691.1 transducin-like enhancer protein 1 isoform X5