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PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Gallus gallus (chicken) ]

Gene ID: 427171, updated on 3-Apr-2024

Summary

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Symbol
PIK3R1provided by CGNC
Full Name
phosphoinositide-3-kinase regulatory subunit 1provided by CGNC
Primary source
CGNC:10965
See related
Ensembl:ENSGALG00010011922
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Z
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (22140431..22200207)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (22140431..22200207)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108553 Neighboring gene uncharacterized LOC121108554 Neighboring gene uncharacterized LOC107051951 Neighboring gene uncharacterized LOC101750551 Neighboring gene solute carrier family 30 member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain. Hofmann BT, et al. Cell Signal, 2012 Oct. PMID 22735814
  2. Infectious bursal disease virus activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of PI3K. Wei L, et al. Virology, 2011 Aug 15. PMID 21723579
  3. Upregulated gga-miR-16-5p Inhibits the Proliferation Cycle and Promotes the Apoptosis of MG-Infected DF-1 Cells by Repressing PIK3R1-Mediated the PI3K/Akt/NF-κB Pathway to Exert Anti-Inflammatory Effect. Zhang K, et al. Int J Mol Sci, 2019 Feb 27. PMID 30818821, Free PMC Article
  4. Effect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activity. Dupont J, et al. Biochem J, 1998 Oct 15. PMID 9761726, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. upregulated gga-miR-16-5p could decrease multiplication, cycle progression, and increase apoptosis of MG-infected DF-1 cells, at least partly through directly targeting PIK3R1
    Title: Upregulated gga-miR-16-5p Inhibits the Proliferation Cycle and Promotes the Apoptosis of MG-Infected DF-1 Cells by Repressing PIK3R1-Mediated the PI3K/Akt/NF-κB Pathway to Exert Anti-Inflammatory Effect.
  2. The deletion of the cSH2 domain enhances the activating effects of the n-terminal SH2 domain (nSH2) mutants K379E and R340E on the PI3K/Akt pathway and micro tumor formation in a focus assay.
    Title: Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.
  3. The role of infectious bursal disease virus proteins in the activation of the P85alpha subunit of phosphatidylinositol 3-kinase and akt proto-oncogene are reported.
    Title: Infectious bursal disease virus activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of PI3K.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha
Names
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22140431..22200207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277626.4 → XP_015133112.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UF03, A0A3Q3ACS4
    Conserved Domains (6) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
    pfam16454
    Location:439 → 598
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  2. XM_424759.8 → XP_424759.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UF03, A0A3Q3ACS4
    Related
    ENSGALP00010016370.1, ENSGALT00010028522.1
    Conserved Domains (6) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
    pfam16454
    Location:439 → 598
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  3. XM_004937313.5 → XP_004937370.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    UniProtKB/TrEMBL
    E1C8M4
    Related
    ENSGALP00010016365.1, ENSGALT00010028517.1
    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  4. XM_004937312.5 → XP_004937369.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_004937369.1

    UniProtKB/TrEMBL
    A0A1D5PUK7
    Related
    ENSGALP00010016364.1, ENSGALT00010028516.1
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

RNA

  1. XR_003072308.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22140431..22200207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046936452.1 → XP_046792408.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q3ACS4

  2. XM_046936451.1 → XP_046792407.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q3ACS4

  3. XM_046936454.1 → XP_046792410.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    UniProtKB/TrEMBL
    E1C8M4

  4. XM_046936453.1 → XP_046792409.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A1D5PUK7

RNA

  1. XR_006937780.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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