IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [Gallus gallus (chicken)] - Gene

Summary

Symbol: IKBKBprovided by CGNC
Full Name: inhibitor of nuclear factor kappa B kinase subunit betaprovided by CGNC
Primary source: CGNC:2733
See related: Ensembl:ENSGALG00010017955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	22	NC_052553.1 (2893700..2905808)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	22	NC_052594.1 (2941207..2953321)

Chromosome 22 - NC_052553.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA sequencing results revealed that the chicken IKBKB was differently expressed between the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease.
Title: Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken.
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
Title: IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables IkappaB kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit beta

Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

NP_001382894.1

EC 2.7.11.10

XP_046759319.1

EC 2.7.11.10

XP_046759320.1

EC 2.7.11.10

XP_046759321.1

EC 2.7.11.10

XP_046787591.1

EC 2.7.11.10

XP_046787592.1

EC 2.7.11.10

XP_046787593.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395965.1 → NP_001382894.1 inhibitor of nuclear factor kappa-B kinase subunit beta

Status: VALIDATED

Source sequence(s)

AJ451632, AJ725107, AJ725109, AJ725110, AJ725111, AJ725112

UniProtKB/TrEMBL

A0A8V0YXK2

Conserved Domains (2) summary

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

cl28922
Location:310 → 386

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2893700..2905808

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046903364.1 → XP_046759320.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
XM_046903363.1 → XP_046759319.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

Related

ENSGALP00010025794.1, ENSGALT00010043394.1
XM_046903365.1 → XP_046759321.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

2941207..2953321

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046931636.1 → XP_046787592.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
XM_046931635.1 → XP_046787591.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
XM_046931637.1 → XP_046787593.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001031397.1: Suppressed sequence

Description

NM_001031397.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.