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Rpn7 Regulatory particle non-ATPase 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42641, updated on 5-May-2024

Summary

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Official Symbol
Rpn7provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 7provided by FlyBase
Primary source
FLYBASE:FBgn0028688
Locus tag
Dmel_CG5378
See related
AllianceGenome:FB:FBgn0028688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
141231_at; anon-WO0172774.103; anon-WO0172774.106; CG5378; Dmel\CG5378; p42A; rpn7; S10a
Summary
Predicted to enable enzyme regulator activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head and organism. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
94A15-94A15; 3-74 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22460662..22462054, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18286384..18287776, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adaptor Protein complex 2, mu subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein. Nikou T, et al. Food Chem Toxicol, 2019 Mar. PMID 30677444
  2. The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set. Kotov AA, et al. Cells, 2020 Feb 26. PMID 32111103, Free PMC Article
  3. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017
  4. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263
  5. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle non-ATPase 7
Names
CG5378-PA
Rpn7-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22460662..22462054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142791.3 → NP_651048.1  regulatory particle non-ATPase 7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651048.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3G7
    Related
    FBpp0083687
    Conserved Domains (3) summary
    COG5187
    Location:15 → 382
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:254 → 358
    PCI; PCI domain
    pfam10602
    Location:66 → 239
    RPN7; 26S proteasome subunit RPN7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3G7.1 Q9V3G7

Gene LinkOut

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