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CG6015 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42593, updated on 10-May-2024

Summary

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Official Symbol
CG6015provided by FlyBase
Primary source
FLYBASE:FBgn0038927
Locus tag
Dmel_CG6015
See related
AllianceGenome:FB:FBgn0038927
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CDC40; Dmel\CG6015; prp17
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human CDC40 (cell division cycle 40). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
94A1-94A1; 3-74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22032150..22034286, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17857872..17860008, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 42 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pitchoune Neighboring gene Fas-associated death domain Neighboring gene small Cajal body-specific RNA : MeU5-G38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes. Yu J, et al. Cell Death Dis, 2021 May 14. PMID 33990549, Free PMC Article
  2. Somatic CG6015 mediates cyst stem cell maintenance and germline stem cell differentiation via EGFR signaling in Drosophila testes. Zheng Q, et al. Cell Death Discov, 2021 Apr 6. PMID 33824283, Free PMC Article
  3. A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation. Rylee J, et al. G3 (Bethesda), 2022 Nov 4. PMID 36218412, Free PMC Article
  4. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article
  5. Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen. Gao Y, et al. J Genet Genomics, 2019 Jan 20. PMID 30745214

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6015-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22032150..22034286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142748.5 → NP_651005.1  uncharacterized protein Dmel_CG6015 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651005.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VD52
    Related
    FBpp0083581
    Conserved Domains (3) summary
    COG2319
    Location:274 → 576
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:277 → 576
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:289 → 327
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VD52 Q9VD52

Gene LinkOut

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