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PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Gallus gallus (chicken) ]

Gene ID: 424971, updated on 3-Apr-2024

Summary

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Symbol
PIK3CAprovided by CGNC
Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by CGNC
Primary source
CGNC:6785
See related
Ensembl:ENSGALG00010018296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
C-P3K
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
25
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (17239903..17278844, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (17032259..17071183, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 4 Neighboring gene mitofusin 1 Neighboring gene zinc finger protein 639 Neighboring gene zinc finger matrin-type 3 Neighboring gene uncharacterized LOC107054084 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Chang HW, et al. Science, 1997 Jun 20. PMID 9188528
  2. Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses. Kang Y, et al. Oncotarget, 2017 Apr 4. PMID 28423596, Free PMC Article
  3. Integrity of the cortical actin ring is required for activation of the PI3K/Akt and p38 MAPK signaling pathways in redifferentiation of chondrocytes on chitosan. Park EH, et al. Cell Biol Int, 2008 Oct. PMID 18703153
  4. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Bader AG, et al. Proc Natl Acad Sci U S A, 2006 Jan 31. PMID 16432179, Free PMC Article
  5. A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: Correlation between Ca(2+)/PKC/MAPKs and PI3K/Akt/mTOR. Lee SH, et al. J Cell Biochem, 2008 Aug 1. PMID 18646054

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that by suppressing premature apoptosis upon Newcastle disease virus (NDV) infection, the PI3K/Akt pathway enhances the anti-apoptotic response.
    Title: Transient activation of the PI3K/Akt pathway promotes Newcastle disease virus replication and enhances anti-apoptotic signaling responses.
  2. These data describe both a novel role for ephrins in palate morphogenesis, and a previously unknown mechanism of ephrin signaling involving PI-3 kinase.
    Title: Ephrin reverse signaling controls palate fusion via a PI3 kinase-dependent mechanism.
  3. These findings suggest that integrity of the actin cytoskeleton is a crucial requirement for PI3K/Akt and p38 MAPK in chondrocyte redifferentiation.
    Title: Integrity of the cortical actin ring is required for activation of the PI3K/Akt and p38 MAPK signaling pathways in redifferentiation of chondrocytes on chitosan.
  4. Short time exposure to hypoxia increases DNA synthesis in primary cultured chicken hepatocytes through cooperation of Ca2+/PKC, p38 MAPK, p44/42 MAPKs, and PI3K/Akt pathways.
    Title: A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: Correlation between Ca(2+)/PKC/MAPKs and PI3K/Akt/mTOR.
  5. Data suggest that the FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin.
    Title: FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470).
  6. PIK3CA mutations are oncogenic in chickens
    Title: Cancer-specific mutations in PIK3CA are oncogenic in vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Names
phosphoinositide 3-kinase catalytic subunit
phosphoinositide-3-kinase, catalytic, alpha polypeptide
NP_001004410.1
XP_046754386.1
XP_046754387.1
XP_046754388.1
XP_046754389.1
XP_046779869.1
XP_046779870.1
XP_046779871.1
XP_046779872.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004410.2 → NP_001004410.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for NP_001004410.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    A0A8V0Z558, O42391
    Related
    ENSGALP00010026266.1, ENSGALT00010044168.1
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17239903..17278844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898433.1 → XP_046754389.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

  2. XM_046898432.1 → XP_046754388.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

  3. XM_046898430.1 → XP_046754386.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

  4. XM_046898431.1 → XP_046754387.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17032259..17071183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046923916.1 → XP_046779872.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

  2. XM_046923915.1 → XP_046779871.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

  3. XM_046923913.1 → XP_046779869.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391

  4. XM_046923914.1 → XP_046779870.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

    UniProtKB/TrEMBL
    O42391
Nucleotide Protein
Heading Accession and Version

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