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PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Gallus gallus (chicken) ]

Gene ID: 424826, updated on 3-Apr-2024

Summary

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Symbol
PIK3CBprovided by CGNC
Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by CGNC
Primary source
CGNC:4100
See related
Ensembl:ENSGALG00010025125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
34
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (5273002..5384565, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (5079258..5346003, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101748697 Neighboring gene period circadian clock 2 Neighboring gene vesicle-associated membrane protein 2 (synaptobrevin 2) Neighboring gene forkhead box L2 Neighboring gene uncharacterized LOC121113443 Neighboring gene mitochondrial ribosomal protein S22 Neighboring gene coatomer protein complex subunit beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decreases in phosphoinositide-3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling activate components of spinal motoneuron death. Newbern J, et al. J Neurochem, 2005 Sep. PMID 16045454
  2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data reveal that changes in PI3K and ERK1/2 signaling lead to individual and overlapping effects on the cell-death machinery
    Title: Decreases in phosphoinositide-3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling activate components of spinal motoneuron death.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Names
phosphoinositide-3-kinase, catalytic, beta polypeptide
NP_001026482.1
XP_015132397.1
XP_015132398.1
XP_015132399.1
XP_015132400.1
XP_015132403.1
XP_025009115.1
XP_025009116.1
XP_046754348.1
XP_046754349.1
XP_046754351.1
XP_046754352.1
XP_046754353.1
XP_046754354.1
XP_046779764.1
XP_046779765.1
XP_046779766.1
XP_046779767.1
XP_046779768.1
XP_046779769.1
XP_046779770.1
XP_046779771.1
XP_046779772.1
XP_046779773.1
XP_046779774.1
XP_046779775.1
XP_046779776.1
XP_046779777.1
XP_046779778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031311.1 → NP_001026482.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    See identical proteins and their annotated locations for NP_001026482.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ851398
    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5273002..5384565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898396.1 → XP_046754352.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  2. XM_046898397.1 → XP_046754353.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  3. XM_015276913.4 → XP_015132399.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  4. XM_025153347.3 → XP_025009115.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Related
    ENSGALP00010037907.1, ENSGALT00010061308.1
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  5. XM_015276911.4 → XP_015132397.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  6. XM_046898393.1 → XP_046754349.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  7. XM_046898392.1 → XP_046754348.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  8. XM_046898395.1 → XP_046754351.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  9. XM_015276912.4 → XP_015132398.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Related
    ENSGALP00010037913.1, ENSGALT00010061316.1
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  10. XM_015276917.3 → XP_015132403.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  11. XM_015276914.4 → XP_015132400.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  12. XM_025153348.3 → XP_025009116.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8V1A672, Q5F4A2
    Conserved Domains (5) summary
    cd08693
    Location:319 → 496
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:175 → 282
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:533 → 698
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:702 → 1063
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:36 → 111
    PI3K_p85B; PI3-kinase family, p85-binding domain

  13. XM_046898398.1 → XP_046754354.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5079258..5346003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046923811.1 → XP_046779767.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  2. XM_046923818.1 → XP_046779774.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  3. XM_046923819.1 → XP_046779775.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  4. XM_046923810.1 → XP_046779766.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  5. XM_046923821.1 → XP_046779777.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  6. XM_046923814.1 → XP_046779770.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  7. XM_046923817.1 → XP_046779773.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  8. XM_046923813.1 → XP_046779769.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  9. XM_046923809.1 → XP_046779765.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  10. XM_046923816.1 → XP_046779772.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  11. XM_046923808.1 → XP_046779764.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  12. XM_046923815.1 → XP_046779771.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  13. XM_046923812.1 → XP_046779768.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  14. XM_046923822.1 → XP_046779778.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2

  15. XM_046923820.1 → XP_046779776.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    Q5F4A2
Nucleotide Protein Strain
Heading Accession and Version

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