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ATR ATR serine/threonine kinase [ Gallus gallus (chicken) ]

Gene ID: 424777, updated on 5-Mar-2024

Summary

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Symbol
ATRprovided by CGNC
Full Name
ATR serine/threonine kinaseprovided by CGNC
Primary source
CGNC:1918
See related
Ensembl:ENSGALG00010015749
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
47
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (10124118..10160141, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (9925418..9961432, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene glycerol kinase 5 (putative) Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene plastin 1 Neighboring gene transient receptor potential cation channel subfamily C member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset. Eykelenboom JK, et al. Cell Rep, 2013 Nov 27. PMID 24268773
  2. ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity. Fujinaka Y, et al. DNA Repair (Amst), 2012 Mar 1. PMID 22188649
  3. Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3. Lian X, et al. J Virol, 2019 May 1. PMID 30787154, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results suggest that MDV disables the ATR-Chk1 pathway through STAT3 activation to benefit its replication.
    Title: Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3.
  2. one of the essential roles of ATR during normal growth is to minimize the level of unreplicated DNA before the onset of mitosis.
    Title: ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset.
  3. These results suggest that Rad9- and Rad17-independent activation of the ATR-Chk1 signaling pathway also significantly contributes to 5-Fluorouracil tolerance.
    Title: ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase ATR
Names
ataxia telangiectasia and Rad3 related
XP_015132446.2
XP_040535307.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10124118..10160141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015276960.4 → XP_015132446.2  serine/threonine-protein kinase ATR

    UniProtKB/TrEMBL
    A0A8V0YTG4, A0A8V0YZV9
    Related
    ENSGALP00010021886.1, ENSGALT00010037925.1
    Conserved Domains (4) summary
    smart00802
    Location:1140 → 1245
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    COG5032
    Location:2142 → 2660
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00892
    Location:2309 → 2583
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    sd00044
    Location:715 → 736
    HEAT; HEAT repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9925418..9961432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040679373.2 → XP_040535307.1  serine/threonine-protein kinase ATR

    UniProtKB/TrEMBL
    A0A8V0YTG4
    Conserved Domains (4) summary
    smart00802
    Location:1140 → 1245
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    COG5032
    Location:2142 → 2660
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00892
    Location:2309 → 2583
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    sd00044
    Location:715 → 736
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
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