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ARHGEF4 Rho guanine nucleotide exchange factor 4 [ Gallus gallus (chicken) ]

Gene ID: 424761, updated on 5-Mar-2024

Summary

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Official Symbol
ARHGEF4provided by CGNC
Official Full Name
Rho guanine nucleotide exchange factor 4provided by CGNC
Primary source
CGNC:1564
See related
Ensembl:ENSGALG00010024234
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (1909855..2112272, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (1778722..1981213, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111497 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene family with sequence similarity 168 member B Neighboring gene collagen alpha-1(III) chain-like Neighboring gene uncharacterized LOC121111498 Neighboring gene APC membrane recruitment protein 3 Neighboring gene G protein-coupled receptor 148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 4
Names
Rho guanine nucleotide exchange factor (GEF) 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1909855..2112272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040706022.2 → XP_040561956.1  rho guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A484
    Related
    ENSGALP00010036086.1, ENSGALT00010059134.1
    Conserved Domains (3) summary
    cd11973
    Location:1904 → 1976
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd00160
    Location:2015 → 2196
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:2202 → 2341
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  2. XM_040706023.2 → XP_040561957.1  rho guanine nucleotide exchange factor 4 isoform X2

    Conserved Domains (3) summary
    cd11973
    Location:100 → 172
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd00160
    Location:211 → 392
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:398 → 537
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  3. XM_046898717.1 → XP_046754673.1  rho guanine nucleotide exchange factor 4 isoform X3

    Conserved Domains (3) summary
    cd00160
    Location:84 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:271 → 410
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:1 → 45
    SH3; Src Homology 3 domain superfamily

  4. XM_040706024.2 → XP_040561958.1  rho guanine nucleotide exchange factor 4 isoform X3

    Conserved Domains (3) summary
    cd00160
    Location:84 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:271 → 410
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:1 → 45
    SH3; Src Homology 3 domain superfamily

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1778722..1981213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040679226.2 → XP_040535160.1  rho guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A484
    Conserved Domains (3) summary
    cd11973
    Location:1904 → 1976
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd00160
    Location:2015 → 2196
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:2202 → 2341
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  2. XM_040679227.2 → XP_040535161.1  rho guanine nucleotide exchange factor 4 isoform X2

    Conserved Domains (3) summary
    cd11973
    Location:100 → 172
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd00160
    Location:211 → 392
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:398 → 537
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  3. XM_046924281.1 → XP_046780237.1  rho guanine nucleotide exchange factor 4 isoform X3

    Conserved Domains (3) summary
    cd00160
    Location:84 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:271 → 410
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:1 → 45
    SH3; Src Homology 3 domain superfamily

  4. XM_040679228.2 → XP_040535162.1  rho guanine nucleotide exchange factor 4 isoform X3

    Conserved Domains (3) summary
    cd00160
    Location:84 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:271 → 410
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:1 → 45
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
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