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MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Gallus gallus (chicken) ]

Gene ID: 424225, updated on 3-Apr-2024

Summary

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Symbol
MAP3K2provided by CGNC
Full Name
mitogen-activated protein kinase kinase kinase 2provided by CGNC
Primary source
CGNC:8740
See related
Ensembl:ENSGALG00010021275
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (23203270..23251223)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (23122278..23170216)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 5 Neighboring gene peroxisomal trans-2-enoyl-CoA reductase Neighboring gene transmembrane protein 169 Neighboring gene uncharacterized LOC121111318 Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene cytochrome P450 family 27 subfamily C member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting. Zhang X, et al. Sci Rep, 2017 Nov 20. PMID 29158522, Free PMC Article
  2. Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens. Rengaraj D, et al. Asian-Australas J Anim Sci, 2017 Jul. PMID 28111433, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data indicated that miR-17-92 promotes chicken cell proliferation at least in part by the upregulation of c-Myc via targeting MAP3K2, and the miR-17-92 cluster, c-Myc and E2F1 form a complex regulatory network in chicken cell proliferation
    Title: MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting.
  2. Real-time qPCR results revealed that the downregulation of chicken miRNA gga-miR-20b-5p in the intestinal mucosal layer of Necrotic enteritis induced Fayoumi chicken line M5.1 was associated with the upregulation of its top-ranking target gene MAP3K2.
    Title: Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 2
XP_015145528.1
XP_015145531.1
XP_040532572.1
XP_040532573.1
XP_040532574.1
XP_040532575.1
XP_040559818.1
XP_046778104.1
XP_046778105.1
XP_046778106.1
XP_046778107.1
XP_046778108.1
XP_046799674.1
XP_046799675.1
XP_046799676.1
XP_046799677.1
XP_046799678.1
XP_422075.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    23203270..23251223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943720.1 → XP_046799676.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZPW4
    Related
    ENSGALP00010030769.1, ENSGALT00010051583.1

  2. XM_046943722.1 → XP_046799678.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZPW4

  3. XM_015290045.4 → XP_015145531.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZHJ3, A0A8V0ZPW4
    Related
    ENSGALP00010030773.1, ENSGALT00010051589.1
    Conserved Domains (2) summary
    cd06405
    Location:34 → 111
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:348 → 611
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  4. XM_422075.8 → XP_422075.3  mitogen-activated protein kinase kinase kinase 2 isoform X3

    See identical proteins and their annotated locations for XP_422075.3

    UniProtKB/TrEMBL
    A0A8V0ZHJ3, A0A8V0ZPW4
    Conserved Domains (2) summary
    cd06405
    Location:34 → 111
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:348 → 611
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  5. XM_015290042.4 → XP_015145528.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZHJ3, A0A8V0ZJ31
    Related
    ENSGALP00010030775.1, ENSGALT00010051592.1
    Conserved Domains (2) summary
    cd06405
    Location:44 → 121
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:358 → 621
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  6. XM_040703884.2 → XP_040559818.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZHJ3
    Conserved Domains (2) summary
    cd06405
    Location:44 → 121
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:357 → 620
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  7. XM_046943721.1 → XP_046799677.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZPW4

  8. XM_046943718.1 → XP_046799674.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJ31

  9. XM_046943719.1 → XP_046799675.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJ31

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    23122278..23170216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922150.1 → XP_046778106.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZPW4

  2. XM_046922152.1 → XP_046778108.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZPW4

  3. XM_040676640.2 → XP_040532574.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZHJ3, A0A8V0ZPW4
    Conserved Domains (2) summary
    cd06405
    Location:34 → 111
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:348 → 611
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  4. XM_040676641.2 → XP_040532575.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZHJ3, A0A8V0ZPW4
    Conserved Domains (2) summary
    cd06405
    Location:34 → 111
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:348 → 611
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  5. XM_040676638.2 → XP_040532572.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZHJ3, A0A8V0ZJ31
    Conserved Domains (2) summary
    cd06405
    Location:44 → 121
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:358 → 621
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  6. XM_040676639.2 → XP_040532573.1  mitogen-activated protein kinase kinase kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZHJ3
    Conserved Domains (2) summary
    cd06405
    Location:44 → 121
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06652
    Location:357 → 620
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

  7. XM_046922151.1 → XP_046778107.1  mitogen-activated protein kinase kinase kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZPW4

  8. XM_046922148.1 → XP_046778104.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJ31

  9. XM_046922149.1 → XP_046778105.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJ31
Nucleotide Protein Strain
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