LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: LSSprovided by CGNC
Official Full Name: lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)provided by CGNC
Primary source: CGNC:4650
See related: Ensembl:ENSGALG00010013452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (6946061..6956132, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (6887941..6898012, complement)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

oxidosqualene cyclase expression and activity are required to maintain erythroid progenitor cell self-renewal and may be involved in the self-renewal versus differentiation/apoptosis decision making, by keeping cells in a self-renewal state
Title: Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables lanosterol synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in triterpenoid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in lipid droplet	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lanosterol synthase

NP_001006514.2

EC 5.4.99.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006514.2 → NP_001006514.2 lanosterol synthase

Status: VALIDATED

Source sequence(s)

AJ453276, AJ724528, AJ724535, AL586203, BM491984, BU240685, BU264667, CD734354

UniProtKB/TrEMBL

A0A8V0YMK4

Related

ENSGALP00010019161.1, ENSGALT00010032394.1

Conserved Domains (2) summary

cd02892
Location:84 → 726

SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...

TIGR01787
Location:83 → 728

squalene_cyclas; squalene/oxidosqualene cyclases

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

6946061..6956132 complement

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GenBank, FASTA, Sequence Viewer (Graphics)