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CHUK component of inhibitor of nuclear factor kappa B kinase complex [ Gallus gallus (chicken) ]

Gene ID: 423669, updated on 3-Apr-2024

Summary

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Official Symbol
CHUKprovided by CGNC
Official Full Name
component of inhibitor of nuclear factor kappa B kinase complexprovided by CGNC
Primary source
CGNC:52021
See related
Ensembl:ENSGALG00010008527
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
IKKA
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (10006760..10029624)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (9890647..9913512)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene leukocyte ribonuclease A-2 Neighboring gene CWF19-like 1, cell cycle control (S. pombe) Neighboring gene small nucleolar RNA SNORA12 Neighboring gene ER lipid raft associated 1 Neighboring gene ADAM metallopeptidase domain 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Lynn DJ, et al. Vet Immunol Immunopathol, 2003 Jun 20. PMID 12814703
  2. Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken. Rengaraj D, et al. Vet Immunol Immunopathol, 2016 Feb. PMID 26872625
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IkappaB kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
Names
IKK-A
IKK-alpha
NFKBIKA
conserved helix-loop-helix ubiquitous kinase
i kappa-B kinase alpha
ikBKA
ikappaB kinase
nuclear factor NF-kappa-B inhibitor kinase alpha
NP_001012922.2
XP_015134161.1
XP_046776088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012904.2 → NP_001012922.2  inhibitor of nuclear factor kappa-B kinase subunit alpha

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000227
    UniProtKB/Swiss-Prot
    Q5ZJB4
    UniProtKB/TrEMBL
    A0A8V0Y749
    Related
    ENSGALP00010011850.1, ENSGALT00010020403.1
    Conserved Domains (2) summary
    cd14039
    Location:35 → 323
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    cd17046
    Location:325 → 401
    Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10006760..10029624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015278675.4 → XP_015134161.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0XUD8
    Related
    ENSGALP00010011854.1, ENSGALT00010020434.1
    Conserved Domains (2) summary
    smart00220
    Location:29 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:35 → 323
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9890647..9913512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046920132.1 → XP_046776088.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZJB4.1 GenPept UniProtKB/Swiss-Prot:Q5ZJB4

Gene LinkOut

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