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Arc42 Activator-recruited cofactor subunit 42 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42364, updated on 4-Apr-2024

Summary

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Official Symbol
Arc42provided by FlyBase
Official Full Name
Activator-recruited cofactor subunit 42provided by FlyBase
Primary source
FLYBASE:FBgn0038742
Locus tag
Dmel_CG4703
See related
AllianceGenome:FB:FBgn0038742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4703; dARC42; Dmel\CG4703
Summary
Predicted to enable acyl-CoA dehydrogenase activity and butyryl-CoA dehydrogenase activity. Predicted to be involved in butyrate catabolic process and fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
92B4-92B4; 3-67 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19877737..19879309)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15703459..15705031)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Multidrug resistance protein 5 Neighboring gene uncharacterized protein Neighboring gene Apoptotic signal-regulating kinase 1 Neighboring gene neither inactivation nor afterpotential E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Sun X, et al. Exp Gerontol, 2010 Mar. PMID 20080168, Free PMC Article
  2. Transcription regulation and animal diversity. Levine M, et al. Nature, 2003 Jul 10. PMID 12853946
  3. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article
  4. The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival. Paiardi C, et al. Genes (Basel), 2017 Apr 28. PMID 28452935, Free PMC Article
  5. RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Wheeler DB, et al. Nat Methods, 2004 Nov. PMID 15782175

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables butyryl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in butyrate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Activator-recruited cofactor subunit 42
Names
Arc42-PA
CG4703-PA
NP_650840.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19877737..19879309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142583.3 → NP_650840.1  Activator-recruited cofactor subunit 42 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDT1
    Related
    FBpp0083227
    Conserved Domains (2) summary
    cd01158
    Location:29 → 401
    SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
    COG1960
    Location:27 → 405
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDT1 Q9VDT1

Gene LinkOut

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