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SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Gallus gallus (chicken) ]

Gene ID: 423572, updated on 5-Mar-2024

Summary

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Symbol
SOS2provided by CGNC
Full Name
SOS Ras/Rho guanine nucleotide exchange factor 2provided by CGNC
Primary source
CGNC:9322
See related
Ensembl:ENSGALG00010019232
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (57482291..57530036, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (57357582..57405361, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene microRNA 1716 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) Neighboring gene cyclin dependent kinase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    57482291..57530036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040701813.2 → XP_040557747.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z370
    Conserved Domains (5) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:773 → 985
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_015276737.4 → XP_015132223.1  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z370, F1N8Q9
    Related
    ENSGALP00010027679.1, ENSGALT00010046491.1
    Conserved Domains (7) summary
    smart00147
    Location:773 → 1017
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4
    pfam00169
    Location:443 → 544
    PH; PH domain
    cl23907
    Location:97 → 147
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    57357582..57405361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040672853.2 → XP_040528787.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z370
    Conserved Domains (5) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:773 → 985
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_040672852.2 → XP_040528786.1  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z370
    Conserved Domains (5) summary
    smart00147
    Location:773 → 1017
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:70 → 169
    Histone; Core histone H2A/H2B/H3/H4
Nucleotide Protein
Heading Accession and Version

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