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SOCS4 suppressor of cytokine signaling 4 [ Gallus gallus (chicken) ]

Gene ID: 423557, updated on 5-Mar-2024

Summary

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Symbol
SOCS4provided by CGNC
Full Name
suppressor of cytokine signaling 4provided by CGNC
Primary source
CGNC:9244
See related
Ensembl:ENSGALG00010018750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (55888339..55901837, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (55929597..55943095, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene galectin 3 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1-like Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene GTP cyclohydrolase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
suppressor of cytokine signaling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199108.2 → NP_001186037.1  suppressor of cytokine signaling 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    F1NEM3
    Related
    ENSGALP00010027062.1, ENSGALT00010045330.1
    Conserved Domains (3) summary
    cd10385
    Location:271 → 371
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:380 → 435
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:62 → 111
    SOCS; Suppressor of cytokine signalling

  2. NM_001397493.1 → NP_001384422.1  suppressor of cytokine signaling 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    F1NEM3
    Related
    ENSGALP00010027043.1, ENSGALT00010045306.1
    Conserved Domains (3) summary
    cd10385
    Location:271 → 371
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:380 → 435
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:62 → 111
    SOCS; Suppressor of cytokine signalling

  3. NM_001397494.1 → NP_001384423.1  suppressor of cytokine signaling 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    F1NEM3
    Related
    ENSGALP00010027058.1, ENSGALT00010045326.1
    Conserved Domains (3) summary
    cd10385
    Location:271 → 371
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:380 → 435
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:62 → 111
    SOCS; Suppressor of cytokine signalling

  4. NM_001397495.1 → NP_001384424.1  suppressor of cytokine signaling 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000215
    UniProtKB/TrEMBL
    F1NEM3
    Related
    ENSGALP00010027051.1, ENSGALT00010045316.1
    Conserved Domains (3) summary
    cd10385
    Location:271 → 371
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:380 → 435
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:62 → 111
    SOCS; Suppressor of cytokine signalling

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    55888339..55901837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040701093.2 → XP_040557027.1  suppressor of cytokine signaling 4 isoform X1

    UniProtKB/TrEMBL
    F1NEM3
    Related
    ENSGALP00010027046.1, ENSGALT00010045310.1
    Conserved Domains (3) summary
    cd10385
    Location:271 → 371
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:380 → 435
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:62 → 111
    SOCS; Suppressor of cytokine signalling

  2. XM_040701095.2 → XP_040557029.1  suppressor of cytokine signaling 4 isoform X1

    UniProtKB/TrEMBL
    F1NEM3
    Conserved Domains (3) summary
    cd10385
    Location:271 → 371
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:380 → 435
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:62 → 111
    SOCS; Suppressor of cytokine signalling

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    55929597..55943095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046918795.1 → XP_046774751.1  suppressor of cytokine signaling 4 isoform X1

    UniProtKB/TrEMBL
    F1NEM3

  2. XM_046918796.1 → XP_046774752.1  suppressor of cytokine signaling 4 isoform X1

    UniProtKB/TrEMBL
    F1NEM3
Nucleotide Protein
Heading Accession and Version

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