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DLL4 delta like canonical Notch ligand 4 [ Gallus gallus (chicken) ]

Gene ID: 423208, updated on 5-Mar-2024

Summary

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Symbol
DLL4provided by CGNC
Full Name
delta like canonical Notch ligand 4provided by CGNC
Primary source
CGNC:6457
See related
Ensembl:ENSGALG00010022311
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (23929187..23940408)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (23896622..23907826)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene ras homolog family member V Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC107053444 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression pattern of Dll4 during chick embryogenesis. Nimmagadda S, et al. Histochem Cell Biol, 2007 Aug. PMID 17605027
  2. Relationship between Delta-like and proneural bHLH genes during chick retinal development. Nelson BR, et al. Dev Dyn, 2008 Jun. PMID 18435466

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dll1 and Dll4 and proneural notch bHLH genes have roles in chick retinal development
    Title: Relationship between Delta-like and proneural bHLH genes during chick retinal development.
  2. Dll4 is expressed in a wide range of tissues and organs suggesting its role in vascular development during chick embryogenesis
    Title: Expression pattern of Dll4 during chick embryogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
delta-like protein 4
Names
delta-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    23929187..23940408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_421132.8 → XP_421132.2  delta-like protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZHH9
    Conserved Domains (3) summary
    cd00054
    Location:436 → 471
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:266 → 328
    DSL; Delta serrate ligand
    pfam07657
    Location:138 → 200
    MNNL; N-terminus of Notch ligand

  2. XM_004941616.5 → XP_004941673.1  delta-like protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZHH9
    Related
    ENSGALP00010032775.1, ENSGALT00010054278.1
    Conserved Domains (3) summary
    cd00054
    Location:321 → 356
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:151 → 213
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 85
    MNNL; N-terminus of Notch ligand

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    23896622..23907826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040671996.2 → XP_040527930.1  delta-like protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZHH9
    Conserved Domains (3) summary
    cd00054
    Location:436 → 471
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:266 → 328
    DSL; Delta serrate ligand
    pfam07657
    Location:138 → 200
    MNNL; N-terminus of Notch ligand

  2. XM_040671997.2 → XP_040527931.1  delta-like protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZHH9
    Conserved Domains (3) summary
    cd00054
    Location:321 → 356
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:151 → 213
    DSL; Delta serrate ligand
    pfam07657
    Location:23 → 85
    MNNL; N-terminus of Notch ligand
Nucleotide Protein
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