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PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [ Gallus gallus (chicken) ]

Gene ID: 423070, updated on 5-Mar-2024

Summary

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Symbol
PIK3C2Aprovided by CGNC
Full Name
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaprovided by CGNC
Primary source
CGNC:4593
See related
Ensembl:ENSGALG00010023209
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
38
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (11369494..11435067, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (11338821..11404404, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A7 Neighboring gene uncharacterized LOC121110974 Neighboring gene uncharacterized LOC112532499 Neighboring gene ribosomal protein S13 Neighboring gene nucleobindin 2 Neighboring gene potassium inwardly rectifying channel subfamily J member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Names
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
phosphoinositide-3-kinase, class 2, alpha polypeptide
XP_004941464.1
XP_015142115.1
XP_015142117.1
XP_040529338.1
XP_040529339.1
XP_040529340.1
XP_040529343.1
XP_040557289.1
XP_046775442.1
XP_046775443.1
XP_046775444.1
XP_046775445.1
XP_046775446.1
XP_046775447.1
XP_046797955.1
XP_046797956.1
XP_046797957.1
XP_046797958.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    11369494..11435067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040701355.2 → XP_040557289.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZLS9
    Conserved Domains (6) summary
    cd07289
    Location:1439 → 1547
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 863
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1576 → 1697
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1056 → 1408
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:434 → 525
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:886 → 1051
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  2. XM_046941999.1 → XP_046797955.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZLS9

  3. XM_004941407.5 → XP_004941464.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_004941464.1

    UniProtKB/TrEMBL
    A0A8V0ZLS9
    Conserved Domains (6) summary
    cd07289
    Location:1439 → 1547
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 863
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1576 → 1697
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1056 → 1408
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:434 → 525
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:886 → 1051
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  4. XM_015286631.4 → XP_015142117.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    UniProtKB/TrEMBL
    E1C1G0
    Related
    ENSGALP00010034332.1, ENSGALT00010056590.1
    Conserved Domains (6) summary
    cd07289
    Location:1437 → 1545
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:690 → 861
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1574 → 1695
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1054 → 1406
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:432 → 523
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:884 → 1049
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  5. XM_015286629.4 → XP_015142115.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZLS9
    Related
    ENSGALP00010034327.1, ENSGALT00010056585.1
    Conserved Domains (6) summary
    cd07289
    Location:1439 → 1547
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 863
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1576 → 1697
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1056 → 1408
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:434 → 525
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:886 → 1051
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  6. XM_046942002.1 → XP_046797958.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

  7. XM_046942001.1 → XP_046797957.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZLS9

  8. XM_046942000.1 → XP_046797956.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZLS9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    11338821..11404404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040673406.2 → XP_040529340.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Conserved Domains (6) summary
    cd07289
    Location:1439 → 1547
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 863
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1576 → 1697
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1056 → 1408
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:886 → 1051
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:422 → 525
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_046919487.1 → XP_046775443.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

  3. XM_046919486.1 → XP_046775442.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

  4. XM_046919488.1 → XP_046775444.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

  5. XM_040673405.2 → XP_040529339.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Conserved Domains (6) summary
    cd07289
    Location:1439 → 1547
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 863
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1576 → 1697
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1056 → 1408
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:886 → 1051
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:422 → 525
    PI3K_rbd; PI3-kinase family, ras-binding domain

  6. XM_040673409.2 → XP_040529343.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    Conserved Domains (6) summary
    cd07289
    Location:1437 → 1545
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:690 → 861
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1574 → 1695
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1054 → 1406
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:884 → 1049
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:420 → 523
    PI3K_rbd; PI3-kinase family, ras-binding domain

  7. XM_040673404.2 → XP_040529338.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Conserved Domains (6) summary
    cd07289
    Location:1439 → 1547
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 863
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1576 → 1697
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1056 → 1408
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:886 → 1051
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:422 → 525
    PI3K_rbd; PI3-kinase family, ras-binding domain

  8. XM_046919491.1 → XP_046775447.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

  9. XM_046919489.1 → XP_046775445.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

  10. XM_046919490.1 → XP_046775446.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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