DRD4 dopamine receptor D4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: DRD4provided by CGNC
Full Name: dopamine receptor D4provided by CGNC
Primary source: CGNC:3783
See related: Ensembl:ENSGALG00010022249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: D4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (744636..750569, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (739226..745159, complement)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cDRD2 and cDRD4 are widely expressed in chicken tissues with abundant expression noted in anterior pituitary
Title: Dopamine D2-like receptors (DRD2 and DRD4) in chickens: Tissue distribution, functional analysis, and their involvement in dopamine inhibition of pituitary prolactin expression.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: D(4) dopamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142849.3 → NP_001136321.1 D(4) dopamine receptor

See identical proteins and their annotated locations for NP_001136321.1

Status: VALIDATED

Source sequence(s)

JAENSK010000212

UniProtKB/TrEMBL

A0A077K7C8, A0A077K915, A0A077K926, A0A809PZ54, A0A809Q2Z9, B6UVA0, F1NYX6

Related

ENSGALP00010032681.1, ENSGALT00010054150.1

Conserved Domains (1) summary

cd15308
Location:46 → 370

7tmA_D4_dopamine_R; D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

744636..750569 complement

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GenBank, FASTA, Sequence Viewer (Graphics)