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MAPK10 mitogen-activated protein kinase 10 [ Gallus gallus (chicken) ]

Gene ID: 422592, updated on 3-Apr-2024

Summary

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Symbol
MAPK10provided by CGNC
Full Name
mitogen-activated protein kinase 10provided by CGNC
Primary source
CGNC:8434
See related
Ensembl:ENSGALG00010003834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. In mammals, this kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (45511448..45610891, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (45451469..45550757, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family member 1 Neighboring gene protein tyrosine phosphatase, non-receptor type 13 Neighboring gene Rho GTPase activating protein 24 Neighboring gene COP9 signalosome subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The expression profile of miR-222b-5p/MAPK10 in spleens of SPF chickens infected with REV-SNV at 28-42 dpi. Jiang H, et al. Pol J Vet Sci, 2021 Sep. PMID 34730307
  2. Evidence of efficient stop codon readthrough in four mammalian genes. Loughran G, et al. Nucleic Acids Res, 2014 Aug. PMID 25013167, Free PMC Article
  3. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression profile of miR-222b-5p/MAPK10 in spleens of SPF chickens infected with REV-SNV at 28-42 dpi.
    Title: The expression profile of miR-222b-5p/MAPK10 in spleens of SPF chickens infected with REV-SNV at 28-42 dpi.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 10
NP_001305153.1
NP_001305154.1
XP_004941160.1
XP_004941162.1
XP_004941163.1
XP_004941164.1
XP_025005406.1
XP_025005407.1
XP_046772063.1
XP_046772064.1
XP_046772065.1
XP_046772066.1
XP_046772067.1
XP_046772068.1
XP_046772069.1
XP_046772070.1
XP_046772071.1
XP_046796087.1
XP_046796088.1
XP_420551.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318224.4 → NP_001305153.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    JAENSK010000073
    UniProtKB/TrEMBL
    A0A8V0XEU2
    Related
    ENSGALP00010005221.1, ENSGALT00010008877.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. NM_001318225.4 → NP_001305154.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the amino acid encoded by the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    JAENSK010000073
    UniProtKB/TrEMBL
    A0A8V0XEU2
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    45511448..45610891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025149638.3 → XP_025005406.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XEU2
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_046940132.1 → XP_046796088.1  mitogen-activated protein kinase 10 isoform X8

  3. XM_025149639.3 → XP_025005407.1  mitogen-activated protein kinase 10 isoform X7

    UniProtKB/TrEMBL
    A0A8V0XEU2
    Related
    ENSGALP00010005214.1, ENSGALT00010008870.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_420551.8 → XP_420551.4  mitogen-activated protein kinase 10 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XEU2
    Conserved Domains (1) summary
    cd07850
    Location:79 → 414
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_046940131.1 → XP_046796087.1  mitogen-activated protein kinase 10 isoform X5

    Related
    ENSGALP00010005218.1, ENSGALT00010008874.1

  6. XM_004941103.5 → XP_004941160.1  mitogen-activated protein kinase 10 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XEU2
    Conserved Domains (1) summary
    cd07850
    Location:79 → 414
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. XM_004941105.5 → XP_004941162.1  mitogen-activated protein kinase 10 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XEU2
    Conserved Domains (1) summary
    cd07850
    Location:79 → 414
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_004941107.5 → XP_004941164.1  mitogen-activated protein kinase 10 isoform X6

    See identical proteins and their annotated locations for XP_004941164.1

    UniProtKB/TrEMBL
    A0A8V0XKB9
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  9. XM_004941106.5 → XP_004941163.1  mitogen-activated protein kinase 10 isoform X6

    See identical proteins and their annotated locations for XP_004941163.1

    UniProtKB/TrEMBL
    A0A8V0XKB9
    Related
    ENSGALP00010005225.1, ENSGALT00010008881.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    45451469..45550757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046916109.1 → XP_046772065.1  mitogen-activated protein kinase 10 isoform X3

  2. XM_046916115.1 → XP_046772071.1  mitogen-activated protein kinase 10 isoform X8

  3. XM_046916114.1 → XP_046772070.1  mitogen-activated protein kinase 10 isoform X7

  4. XM_046916108.1 → XP_046772064.1  mitogen-activated protein kinase 10 isoform X2

  5. XM_046916111.1 → XP_046772067.1  mitogen-activated protein kinase 10 isoform X5

  6. XM_046916107.1 → XP_046772063.1  mitogen-activated protein kinase 10 isoform X1

  7. XM_046916110.1 → XP_046772066.1  mitogen-activated protein kinase 10 isoform X4

  8. XM_046916112.1 → XP_046772068.1  mitogen-activated protein kinase 10 isoform X6

  9. XM_046916113.1 → XP_046772069.1  mitogen-activated protein kinase 10 isoform X6

Nucleotide Protein
Heading Accession and Version

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