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Cpsf73 Cleavage and polyadenylation specificity factor 73 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42240, updated on 10-May-2024

Summary

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Official Symbol
Cpsf73provided by FlyBase
Official Full Name
Cleavage and polyadenylation specificity factor 73provided by FlyBase
Primary source
FLYBASE:FBgn0261065
Locus tag
Dmel_CG7698
See related
AllianceGenome:FB:FBgn0261065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7698; cpsf-73; CPSF-73; CPSF73; dCPSF-73; Dmel\CG7698
Summary
Predicted to enable 5'-3' exonuclease activity; RNA binding activity; and endoribonuclease activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA polyadenylation. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including embryonic brain; embryonic/larval midgut; endoderm anlage; extended germ band embryo; and germ layer. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
91B8-91B8; 3-64 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18661121..18663552, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14486843..14489274, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene qin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cleavage stimulation factor 64 kD subunit Neighboring gene uncharacterized protein Neighboring gene Golgi SNARE, 28 kDa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. Michalski D, et al. RNA, 2015 Aug. PMID 26081560, Free PMC Article
  2. EM visualization of Pol II genes in Drosophila: most genes terminate without prior 3' end cleavage of nascent transcripts. Osheim YN, et al. Chromosoma, 2002 Mar. PMID 12068918
  3. Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations. Harrington AW, et al. BMC Genomics, 2017 Apr 17. PMID 28415970, Free PMC Article
  4. Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Skrajna A, et al. Nucleic Acids Res, 2018 May 18. PMID 29529248, Free PMC Article
  5. Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors. Chen YA, et al. Mol Cell, 2016 Jul 7. PMID 27292797, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cleavage and polyadenylation specificity factor 73
Names
CG7698-PA
Cpsf73-PA
cleavage and polyadenylation specificity factor, 73kD-subunit
NP_650738.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18661121..18663552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142481.3 → NP_650738.1  cleavage and polyadenylation specificity factor 73 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650738.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VE51
    Related
    FBpp0083105
    Conserved Domains (5) summary
    smart01027
    Location:252 → 373
    Beta-Casp; Beta-Casp domain
    smart01098
    Location:483 → 683
    CPSF73-100_C; This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins
    COG1236
    Location:18 → 456
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:386 → 426
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16292
    Location:18 → 211
    CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VE51.2 Q9VE51

Gene LinkOut

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