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CstF64 Cleavage stimulation factor 64 kD subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42239, updated on 10-May-2024

Summary

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Official Symbol
CstF64provided by FlyBase
Official Full Name
Cleavage stimulation factor 64 kD subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0027841
Locus tag
Dmel_CG7697
See related
AllianceGenome:FB:FBgn0027841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7697; CstF 64; CStF 64; CstF-64; dCstF64; Dmel\CG7697
Summary
Predicted to enable mRNA binding activity. Involved in positive regulation of autophagy. Part of mRNA cleavage stimulating factor complex. Is expressed in organism. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2) and CSTF2T (cleavage stimulation factor subunit 2 tau variant). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
91B8-91B8; 3-64 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18659618..18661126)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14485340..14486848)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene qin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cleavage and polyadenylation specificity factor 73 Neighboring gene uncharacterized protein Neighboring gene Golgi SNARE, 28 kDa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif. Salisbury J, et al. BMC Genomics, 2006 Mar 16. PMID 16542450, Free PMC Article
  2. ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Soller M, et al. Genes Dev, 2003 Oct 15. PMID 14522950, Free PMC Article
  3. The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene. Hatton LS, et al. Nucleic Acids Res, 2000 Jan 15. PMID 10606651, Free PMC Article
  4. Drosophila Sex-lethal protein mediates polyadenylation switching in the female germline. Gawande B, et al. EMBO J, 2006 Mar 22. PMID 16511567, Free PMC Article
  5. Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Skrajna A, et al. Nucleic Acids Res, 2018 May 18. PMID 29529248, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage stimulating factor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cleavage stimulation factor 64 kD subunit
Names
CG7697-PA
CstF64-PA
cleavage stimulation factor
cleavage stimulation factor 64 kilodalton subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18659618..18661126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058105.5 → NP_477453.1  cleavage stimulation factor 64 kD subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477453.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NL1, Q9U4J2, Q9VE52
    Related
    FBpp0083075
    Conserved Domains (4) summary
    COG0724
    Location:13 → 112
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12671
    Location:18 → 92
    RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
    pfam14304
    Location:377 → 416
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:112 → 190
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86NL1 Q86NL1
Q9VE52 Q9VE52

Gene LinkOut

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