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PAK3 p21 (RAC1) activated kinase 3 [ Gallus gallus (chicken) ]

Gene ID: 422342, updated on 5-Mar-2024

Summary

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Symbol
PAK3provided by CGNC
Full Name
p21 (RAC1) activated kinase 3provided by CGNC
Primary source
CGNC:6100
See related
Ensembl:ENSGALG00010015443
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (13344145..13453345, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (13376396..13485510, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene doublecortin Neighboring gene calpain 6 Neighboring gene microRNA 1606 Neighboring gene chordin like 1 Neighboring gene AMMECR nuclear protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties. Kreis P, et al. J Neurochem, 2008 Aug. PMID 18507705

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The peptide sequence of PAK3 exon b in Gallus (PDLYGSQMCTGKLPE) shows one amino acid substitution compared with mammals.
    Title: The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase PAK 3
Names
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
XP_015134084.1
XP_015134085.1
XP_040526515.1
XP_040526516.1
XP_040526517.1
XP_040526518.1
XP_040556074.2
XP_046773307.1
XP_046796465.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    13344145..13453345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015278599.4 → XP_015134085.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    F1N8W8
    Related
    ENSGALP00010021552.1, ENSGALT00010037073.1
    Conserved Domains (2) summary
    cd06656
    Location:247 → 543
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  2. XM_046940509.1 → XP_046796465.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    F1N8W8

  3. XM_015278598.4 → XP_015134084.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    F1N8W8
    Conserved Domains (2) summary
    cd06656
    Location:247 → 543
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  4. XM_040700140.2 → XP_040556074.2  serine/threonine-protein kinase PAK 3 isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    13376396..13485510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040670584.2 → XP_040526518.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    F1N8W8
    Conserved Domains (2) summary
    cd06656
    Location:247 → 543
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  2. XM_040670581.2 → XP_040526515.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YYX2
    Conserved Domains (2) summary
    cd06656
    Location:262 → 558
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    cd01093
    Location:68 → 128
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  3. XM_046917351.1 → XP_046773307.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YYX2

  4. XM_040670583.2 → XP_040526517.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    F1N8W8
    Conserved Domains (2) summary
    cd06656
    Location:247 → 543
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69 → 126
    PBD; P21-Rho-binding domain

  5. XM_040670582.2 → XP_040526516.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YYX2
    Conserved Domains (2) summary
    cd06656
    Location:262 → 558
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    cd01093
    Location:68 → 128
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein
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