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ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Gallus gallus (chicken) ]

Gene ID: 422247, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGEF6provided by CGNC
Official Full Name
Rac/Cdc42 guanine nucleotide exchange factor 6provided by CGNC
Primary source
CGNC:4852
See related
Ensembl:ENSGALG00010015866
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (4329627..4360771, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (4365105..4396257, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene vestigial like family member 1 Neighboring gene CD40 ligand Neighboring gene uncharacterized LOC121110712 Neighboring gene RBMX like 1 Neighboring gene small nucleolar RNA SNORD61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 6
Names
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006432.2 → NP_001006432.1  rho guanine nucleotide exchange factor 6

    See identical proteins and their annotated locations for NP_001006432.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000071
    UniProtKB/Swiss-Prot
    Q5ZLR6
    UniProtKB/TrEMBL
    A0A8V0YTK9
    Related
    ENSGALP00010022072.1, ENSGALT00010038240.1
    Conserved Domains (8) summary
    cd12060
    Location:154 → 211
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5 → 103
    CH; Calponin homology domain
    cd01225
    Location:442 → 540
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:442 → 540
    PH; PH domain
    pfam00621
    Location:237 → 412
    RhoGEF; RhoGEF domain
    pfam16523
    Location:669 → 755
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:560 → 666
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:114 → 152
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4329627..4360771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040698815.2 → XP_040554749.1  rho guanine nucleotide exchange factor 6 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Related
    ENSGALP00010022069.1, ENSGALT00010038236.1
    Conserved Domains (5) summary
    cd12060
    Location:163 → 220
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5 → 103
    CH; Calponin homology domain
    cd00160
    Location:246 → 420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:451 → 549
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:567 → 668
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  2. XM_015278264.4 → XP_015133750.1  rho guanine nucleotide exchange factor 6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Conserved Domains (8) summary
    cd12060
    Location:163 → 220
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5 → 103
    CH; Calponin homology domain
    cd01225
    Location:451 → 549
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:451 → 549
    PH; PH domain
    pfam00621
    Location:246 → 421
    RhoGEF; RhoGEF domain
    pfam16523
    Location:678 → 764
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:569 → 675
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:114 → 161
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. XM_040698819.2 → XP_040554753.1  rho guanine nucleotide exchange factor 6 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Conserved Domains (5) summary
    cd12060
    Location:8 → 65
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:91 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:412 → 513
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:516 → 602
    betaPIX_CC; betaPIX coiled coil

  4. XM_040698820.2 → XP_040554754.1  rho guanine nucleotide exchange factor 6 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Conserved Domains (5) summary
    cd12060
    Location:8 → 65
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:91 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:412 → 513
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:516 → 602
    betaPIX_CC; betaPIX coiled coil

  5. XM_025149561.3 → XP_025005329.1  rho guanine nucleotide exchange factor 6 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Related
    ENSGALP00010022060.1, ENSGALT00010038222.1
    Conserved Domains (5) summary
    cd12060
    Location:8 → 65
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:91 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:412 → 513
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:516 → 602
    betaPIX_CC; betaPIX coiled coil

  6. XM_025149560.3 → XP_025005328.1  rho guanine nucleotide exchange factor 6 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Conserved Domains (5) summary
    cd12060
    Location:8 → 65
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:91 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:523 → 609
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:414 → 520
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  7. XM_040698818.2 → XP_040554752.1  rho guanine nucleotide exchange factor 6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Conserved Domains (5) summary
    cd12060
    Location:163 → 220
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5 → 103
    CH; Calponin homology domain
    cd00160
    Location:246 → 420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:451 → 549
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:567 → 638
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  8. XM_040698816.2 → XP_040554750.1  rho guanine nucleotide exchange factor 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YTK9
    Conserved Domains (5) summary
    cd12060
    Location:163 → 220
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:5 → 103
    CH; Calponin homology domain
    cd00160
    Location:246 → 420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:451 → 549
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:567 → 645
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4365105..4396257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915788.1 → XP_046771744.1  rho guanine nucleotide exchange factor 6 isoform X2

  2. XM_046915787.1 → XP_046771743.1  rho guanine nucleotide exchange factor 6 isoform X1

  3. XM_046915793.1 → XP_046771749.1  rho guanine nucleotide exchange factor 6 isoform X6

  4. XM_046915794.1 → XP_046771750.1  rho guanine nucleotide exchange factor 6 isoform X6

  5. XM_046915792.1 → XP_046771748.1  rho guanine nucleotide exchange factor 6 isoform X6

  6. XM_046915791.1 → XP_046771747.1  rho guanine nucleotide exchange factor 6 isoform X5

  7. XM_046915790.1 → XP_046771746.1  rho guanine nucleotide exchange factor 6 isoform X4

  8. XM_046915789.1 → XP_046771745.1  rho guanine nucleotide exchange factor 6 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZLR6.1 GenPept UniProtKB/Swiss-Prot:Q5ZLR6

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