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ADAM17 ADAM metallopeptidase domain 17 [ Gallus gallus (chicken) ]

Gene ID: 421931, updated on 3-Apr-2024

Summary

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Symbol
ADAM17provided by CGNC
Full Name
ADAM metallopeptidase domain 17provided by CGNC
Primary source
CGNC:12298
See related
Ensembl:ENSGALG00010003348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TACE
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (95904091..95936588, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (95719928..95752432, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog Neighboring gene uncharacterized LOC121110473 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development. Lin J, et al. Int J Dev Biol, 2011. PMID 22252493
  2. Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development. Markus A, et al. Cell Mol Biol Lett, 2011 Sep. PMID 21786032, Free PMC Article
  3. Differential regional expression of multiple ADAMs during feather bud formation. Lin J, et al. Dev Dyn, 2011 Sep. PMID 21780243
  4. The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing. Carrodeguas JA, et al. Neuroscience, 2005. PMID 16039787
  5. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. overexpression of ADAM17 in the developing tectum promotes angiogenesis by increasing the number of pericytes and capillary sprouting in the radial vessels
    Title: ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development.
  2. ADAM9, ADAM10, and ADAM17 are expressed in the epidermis of the feather bud.
    Title: Differential regional expression of multiple ADAMs during feather bud formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
tumor necrosis factor alpha converting enzyme
NP_001008682.2
XP_046770116.1
XP_046770117.1
XP_046794885.1
XP_046794886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008682.2 → NP_001008682.2  disintegrin and metalloproteinase domain-containing protein 17 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000066
    UniProtKB/TrEMBL
    Q5QHR9
    Related
    ENSGALP00010004718.1, ENSGALT00010007862.1
    Conserved Domains (3) summary
    smart00050
    Location:484 → 560
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223 → 477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    cd14246
    Location:580 → 642
    ADAM17_MPD; Membrane-proximal domain of a disintegrin and metalloprotease 17 (ADAM17)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    95904091..95936588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938930.1 → XP_046794886.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDF8
    Related
    ENSGALP00010004703.1, ENSGALT00010007841.1

  2. XM_046938929.1 → XP_046794885.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDF8

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    95719928..95752432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046914161.1 → XP_046770117.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDF8

  2. XM_046914160.1 → XP_046770116.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDF8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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