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LYN LYN proto-oncogene, Src family tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 421127, updated on 11-Apr-2024

Summary

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Symbol
LYNprovided by CGNC
Full Name
LYN proto-oncogene, Src family tyrosine kinaseprovided by CGNC
Primary source
CGNC:51418
See related
Ensembl:ENSGALG00010004746
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (110833081..110880252)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (110878432..110925639)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene trimethylguanosine synthase 1 Neighboring gene uncharacterized LOC112531857 Neighboring gene kinesin family member 20A-like Neighboring gene small nucleolar RNA U54 Neighboring gene uncharacterized LOC124418326 Neighboring gene ribosomal protein S20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction. He S, et al. Vet Microbiol, 2020 Aug. PMID 32768227
  2. Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. Chung SC, et al. J Cell Biol, 2007 Apr 23. PMID 17452533, Free PMC Article
  3. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters. Lösing M, et al. J Biol Chem, 2013 Jan 25. PMID 23223229, Free PMC Article
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction.
    Title: Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction.
  2. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
    Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
  3. The simultaneous but not the independent suppression of Lyn and Syk expression prevents the activation of Ca2+-release activated Ca2+ current without interfering with thapsigargin-sensitive Ca(2+) store release in DT40 B lymphocyte cells.
    Title: Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Lyn
Names
lyn protein non-receptor kinase
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
NP_001006390.1
XP_040541350.1
XP_040541351.1
XP_040541352.1
XP_040541354.1
XP_040541355.1
XP_040541356.1
XP_040541358.1
XP_040541359.1
XP_040541360.1
XP_040541361.1
XP_040541362.1
XP_040541363.1
XP_040541364.1
XP_046767539.1
XP_046767540.1
XP_046767541.1
XP_046767542.1
XP_046767543.1
XP_046767544.1
XP_046767545.1
XP_046767546.1
XP_046767547.1
XP_046767548.1
XP_046767549.1
XP_046767550.1
XP_046767551.1
XP_046767552.1
XP_046767553.1
XP_046767554.1
XP_046767555.1
XP_046767556.1
XP_046767557.1
XP_046781304.1
XP_046781324.1
XP_046781331.1
XP_046781352.1
XP_046781374.1
XP_046781381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006390.2 → NP_001006390.1  tyrosine-protein kinase Lyn

    See identical proteins and their annotated locations for NP_001006390.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000043
    UniProtKB/TrEMBL
    A0A8V0XQ54, F1NUU2, Q5ZMB9
    Conserved Domains (3) summary
    cd10364
    Location:105 → 205
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:47 → 102
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:219 → 490
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    110833081..110880252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046925348.1 → XP_046781304.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  2. XM_046925396.1 → XP_046781352.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  3. XM_040685422.2 → XP_040541356.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  4. XM_040685427.2 → XP_040541361.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8V0XQ54, F1NUU2, Q5ZMB9
    Conserved Domains (3) summary
    cd10364
    Location:105 → 205
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:47 → 102
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:219 → 490
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  5. XM_040685416.2 → XP_040541350.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Related
    ENSGALP00010006310.1, ENSGALT00010011084.1
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  6. XM_040685421.2 → XP_040541355.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Related
    ENSGALP00010006309.1, ENSGALT00010011082.1
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  7. XM_046925425.1 → XP_046781381.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  8. XM_040685425.2 → XP_040541359.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  9. XM_046925368.1 → XP_046781324.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  10. XM_046925418.1 → XP_046781374.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  11. XM_040685424.2 → XP_040541358.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  12. XM_040685429.2 → XP_040541363.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8V0XQ54, F1NUU2, Q5ZMB9
    Conserved Domains (3) summary
    cd10364
    Location:105 → 205
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:47 → 102
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:219 → 490
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  13. XM_046925375.1 → XP_046781331.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  14. XM_040685418.2 → XP_040541352.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Related
    ENSGALP00010006291.1, ENSGALT00010011042.1
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  15. XM_040685428.2 → XP_040541362.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8V0XQ54, F1NUU2, Q5ZMB9
    Related
    ENSGALP00010006293.1, ENSGALT00010011053.1
    Conserved Domains (3) summary
    cd10364
    Location:105 → 205
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:47 → 102
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:219 → 490
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  16. XM_040685417.2 → XP_040541351.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  17. XM_040685426.2 → XP_040541360.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8V0XQ54, F1NUU2, Q5ZMB9
    Conserved Domains (3) summary
    cd10364
    Location:105 → 205
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:47 → 102
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:219 → 490
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  18. XM_040685420.2 → XP_040541354.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDS4, A0A8V0XHW1, A0A8V0XQ59
    Related
    ENSGALP00010006306.1, ENSGALT00010011076.1
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  19. XM_040685430.2 → XP_040541364.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8V0XQ54, F1NUU2, Q5ZMB9
    Related
    ENSGALP00010006283.1, ENSGALT00010011023.1
    Conserved Domains (3) summary
    cd10364
    Location:105 → 205
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:47 → 102
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:219 → 490
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    110878432..110925639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911585.1 → XP_046767541.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  2. XM_046911595.1 → XP_046767551.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  3. XM_046911587.1 → XP_046767543.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  4. XM_046911597.1 → XP_046767553.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  5. XM_046911584.1 → XP_046767540.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  6. XM_046911591.1 → XP_046767547.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  7. XM_046911601.1 → XP_046767557.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  8. XM_046911593.1 → XP_046767549.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  9. XM_046911590.1 → XP_046767546.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  10. XM_046911600.1 → XP_046767556.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  11. XM_046911589.1 → XP_046767545.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  12. XM_046911598.1 → XP_046767554.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  13. XM_046911583.1 → XP_046767539.1  tyrosine-protein kinase Lyn isoform X3

    UniProtKB/TrEMBL
    A0A8V0XHX5

  14. XM_046911594.1 → XP_046767550.1  tyrosine-protein kinase Lyn isoform X4

  15. XM_046911592.1 → XP_046767548.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  16. XM_046911586.1 → XP_046767542.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  17. XM_046911596.1 → XP_046767552.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9

  18. XM_046911588.1 → XP_046767544.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHW1

  19. XM_046911599.1 → XP_046767555.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    F1NUU2, Q5ZMB9
Nucleotide Protein Strain
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