U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SOCS6 suppressor of cytokine signaling 6 [ Gallus gallus (chicken) ]

Gene ID: 421020, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Symbol
SOCS6provided by CGNC
Full Name
suppressor of cytokine signaling 6provided by CGNC
Primary source
CGNC:10278
See related
Ensembl:ENSGALG00010001225
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (93148584..93176550, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (93232502..93260493, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112531828 Neighboring gene uncharacterized LOC112531829 Neighboring gene microRNA 6584 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene uncharacterized LOC124417735 Neighboring gene rotatin Neighboring gene CD226 molecule

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6). Fu M, et al. Virus Res, 2018 Jul 2. PMID 29777734

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gga-miR-454 increased the expression of IFN-beta by targeting SOCS6, enhancing the antiviral response of host cells. These findings highlight a crucial role of gga-miR-454 in host defense against infectious bursal disease virus infection.
    Title: gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6).
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
suppressor of cytokine signaling 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127312.1 → NP_001120784.1  suppressor of cytokine signaling 6

    See identical proteins and their annotated locations for NP_001120784.1

    Status: PROVISIONAL

    Source sequence(s)
    EF544593
    UniProtKB/TrEMBL
    B2WUP2
    Related
    ENSGALP00010001386.1, ENSGALT00010002836.1
    Conserved Domains (2) summary
    cd10387
    Location:372 → 471
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:494 → 534
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    93148584..93176550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015282391.4 → XP_015137877.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    B2WUP2
    Related
    ENSGALP00010001385.1, ENSGALT00010002835.1
    Conserved Domains (2) summary
    cd10387
    Location:372 → 471
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:494 → 534
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  2. XM_015282390.4 → XP_015137876.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    B2WUP2
    Related
    ENSGALP00010001391.1, ENSGALT00010002841.1
    Conserved Domains (2) summary
    cd10387
    Location:372 → 471
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:494 → 534
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  3. XM_046924961.1 → XP_046780917.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    B2WUP2
    Related
    ENSGALP00010001383.1, ENSGALT00010002833.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    93232502..93260493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911486.1 → XP_046767442.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    B2WUP2

  2. XM_046911485.1 → XP_046767441.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    B2WUP2

  3. XM_046911487.1 → XP_046767443.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/TrEMBL
    B2WUP2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.