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TERT telomerase reverse transcriptase [ Gallus gallus (chicken) ]

Gene ID: 420972, updated on 3-Apr-2024

Summary

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Symbol
TERTprovided by CGNC
Full Name
telomerase reverse transcriptaseprovided by CGNC
Primary source
CGNC:9953
See related
Ensembl:ENSGALG00010008150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
chTERT
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (85359798..85401889, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (85433119..85475194, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 19 Neighboring gene uncharacterized LOC107052652 Neighboring gene solute carrier family 6 member 18 Neighboring gene uncharacterized LOC107052651 Neighboring gene CLPTM1 like Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene uncharacterized LOC121109622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/β-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells. Xiang Y, et al. Vet Res, 2021 Aug 19. PMID 34412690, Free PMC Article
  2. ICP27 protein of Marek's disease virus interacts with SR proteins and inhibits the splicing of cellular telomerase chTERT and viral vIL8 transcripts. Amor S, et al. J Gen Virol, 2011 Jun. PMID 21325479
  3. Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo. Amor S, et al. BMC Cancer, 2010 Oct 21. PMID 20964812, Free PMC Article
  4. Telomerase reverse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas. Yang F, et al. Proc Natl Acad Sci U S A, 2007 Nov 27. PMID 18024587, Free PMC Article
  5. Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity. Chang H, et al. Gene, 2006 Sep 1. PMID 16806743

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/beta-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells.
    Title: Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/β-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells.
  2. MYC, TERT, and ZIC1 genes are common targets of viral integration.
    Title: The MYC, TERT, and ZIC1 genes are common targets of viral integration and transcriptional deregulation in avian leukosis virus subgroup J-induced myeloid leukosis.
  3. in chicken cells, alternatively spliced TERT variants containing internal deletions or insertions that eliminated or reduced telomerase activity enhanced cell proliferation.
    Title: Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.
  4. ICP27 protein of Marek's disease virus inhibits the splicing of cellular telomerase chTERT.
    Title: ICP27 protein of Marek's disease virus interacts with SR proteins and inhibits the splicing of cellular telomerase chTERT and viral vIL8 transcripts.
  5. TERT regulation by splicing plays a key role in telomerase upregulation during lymphomagenesis, through the sophisticated control of constitutive and alternative splicing
    Title: Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo.
  6. IRF-4 and IRF-8, two lymphoid cell-specific transcription factors, increase telomerase activity by activating TERT transcription in immune cells.
    Title: Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells.
  7. Avian leukosis virus upregulates cellular TERT by insertional activation to initiate or enhance tumor progression. Provirus integrated 217 to 2,584 bp upstream of the transcription initiation site and were all in the opposite transcriptional orientation.
    Title: Telomerase reverse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas.
  8. The results support that alternative splicing of TERT, in chicken, contributes to telomerase activity regulation.
    Title: Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables telomerase RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomerase RNA reverse transcriptase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of telomerase catalytic core complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
telomerase reverse transcriptase
NP_001026178.2
NP_001385251.1
XP_040540209.1
XP_040540215.1
XP_040540225.1
XP_040540236.1
XP_040540262.1
XP_046767413.1
XP_046767414.1
XP_046767415.1
XP_046767416.1
XP_046767417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031007.2 → NP_001026178.2  telomerase reverse transcriptase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000041
    UniProtKB/TrEMBL
    A0A8V0XS11
    Related
    ENSGALP00010010989.1, ENSGALT00010019441.1

  2. NM_001398322.1 → NP_001385251.1  telomerase reverse transcriptase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000041
    Conserved Domains (2) summary
    smart00975
    Location:669 → 802
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:977 → 1089
    TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    85359798..85401889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040684291.2 → XP_040540225.1  telomerase reverse transcriptase isoform X5

    UniProtKB/TrEMBL
    Q537V4
    Conserved Domains (2) summary
    smart00975
    Location:627 → 760
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:1008 → 1120
    TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

  2. XM_040684328.2 → XP_040540262.1  telomerase reverse transcriptase isoform X4

    Conserved Domains (2) summary
    cd01648
    Location:597 → 709
    TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...
    cl13446
    Location:281 → 349
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain

  3. XM_040684302.2 → XP_040540236.1  telomerase reverse transcriptase isoform X3

    UniProtKB/TrEMBL
    A0A8V0XYA0, Q537V4
    Related
    ENSGALP00010010991.1, ENSGALT00010019443.1
    Conserved Domains (2) summary
    smart00975
    Location:669 → 802
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:989 → 1101
    TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

  4. XM_040684281.2 → XP_040540215.1  telomerase reverse transcriptase isoform X2

    UniProtKB/TrEMBL
    Q537V4
    Conserved Domains (2) summary
    smart00975
    Location:669 → 802
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:1050 → 1138
    TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

  5. XM_040684275.2 → XP_040540209.1  telomerase reverse transcriptase isoform X1

    UniProtKB/TrEMBL
    A0A8V0XWC6, Q537V4
    Related
    ENSGALP00010010988.1, ENSGALT00010019440.1
    Conserved Domains (2) summary
    smart00975
    Location:669 → 802
    Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    cd01648
    Location:1050 → 1162
    TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

RNA

  1. XR_005854353.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    85433119..85475194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911460.1 → XP_046767416.1  telomerase reverse transcriptase isoform X6

  2. XM_046911461.1 → XP_046767417.1  telomerase reverse transcriptase isoform X4

  3. XM_046911459.1 → XP_046767415.1  telomerase reverse transcriptase isoform X3

  4. XM_046911458.1 → XP_046767414.1  telomerase reverse transcriptase isoform X2

  5. XM_046911457.1 → XP_046767413.1  telomerase reverse transcriptase isoform X1

RNA

  1. XR_006933417.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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