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GRB10 growth factor receptor bound protein 10 [ Gallus gallus (chicken) ]

Gene ID: 420948, updated on 3-Apr-2024

Summary

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Symbol
GRB10provided by CGNC
Full Name
growth factor receptor bound protein 10provided by CGNC
Primary source
CGNC:9904
See related
Ensembl:ENSGALG00010000674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (80480880..80622632, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (80530396..80638101, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene SUN domain-containing protein 3-like Neighboring gene SUN domain-containing protein 3-like Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene uncharacterized LOC107052647

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth factor receptor-bound protein 10
Names
adapter protein
binds to insulin receptor and IGF1R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039282.4 → NP_001034371.2  growth factor receptor-bound protein 10

    See identical proteins and their annotated locations for NP_001034371.2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000041
    UniProtKB/TrEMBL
    A0A1D5P405, Q5QJU5
    Conserved Domains (4) summary
    cd10415
    Location:489 → 596
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:288 → 410
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:167 → 257
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:428 → 469
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    80480880..80622632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025147273.3 → XP_025003041.1  growth factor receptor-bound protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P405, Q5QJU5
    Related
    ENSGALP00010000762.1, ENSGALT00010001417.1
    Conserved Domains (4) summary
    cd10415
    Location:489 → 596
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:288 → 410
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:167 → 257
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:428 → 469
    BPS; BPS (Between PH and SH2)

  2. XM_015282308.4 → XP_015137794.1  growth factor receptor-bound protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P405, Q5QJU5
    Conserved Domains (4) summary
    cd10415
    Location:489 → 596
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:288 → 410
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:167 → 257
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:428 → 469
    BPS; BPS (Between PH and SH2)

  3. XM_046924477.1 → XP_046780433.1  growth factor receptor-bound protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P405

  4. XM_015282309.4 → XP_015137795.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8V0X5W7, Q5QJU5
    Related
    ENSGALP00010000763.1, ENSGALT00010001420.1
    Conserved Domains (4) summary
    cd01787
    Location:167 → 248
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:450 → 557
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:288 → 410
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:293 → 401
    PH; PH domain

  5. XM_040684208.2 → XP_040540142.1  growth factor receptor-bound protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P405, Q5QJU5
    Conserved Domains (4) summary
    cd10415
    Location:489 → 596
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:288 → 410
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:167 → 257
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
    pfam08947
    Location:428 → 469
    BPS; BPS (Between PH and SH2)

  6. XM_040684209.2 → XP_040540143.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    Q5QJU5
    Conserved Domains (3) summary
    cd10415
    Location:447 → 554
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:246 → 368
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16141
    Location:125 → 215
    RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

  7. XM_046924480.1 → XP_046780436.1  growth factor receptor-bound protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8V0X3H6
    Related
    ENSGALP00010000760.1, ENSGALT00010001412.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    80530396..80638101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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