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GLI3 GLI family zinc finger 3 [ Gallus gallus (chicken) ]

Gene ID: 420769, updated on 3-Apr-2024

Summary

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Symbol
GLI3provided by CGNC
Full Name
GLI family zinc finger 3provided by CGNC
Primary source
CGNC:9366
See related
Ensembl:ENSGALG00010007884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GLI3FL
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (50701998..50913787, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (50756375..50968180, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109778 Neighboring gene uncharacterized LOC101749489 Neighboring gene uncharacterized LOC101749620 Neighboring gene uncharacterized LOC124417760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An N-terminal G11A mutation in HOXD13 causes synpolydactyly and interferes with Gli3R function during limb pre-patterning. Brison N, et al. Hum Mol Genet, 2012 Jun 1. PMID 22373878
  2. Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma. Ying M, et al. J Cancer Res Clin Oncol, 2010 Oct. PMID 20155426
  3. Similar expression and regulation of Gli2 and Gli3 in the chick limb bud. Schweitzer R, et al. Mech Dev, 2000 Nov. PMID 11044624
  4. The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Low WC, et al. Dev Biol, 2008 Sep 1. PMID 18590719, Free PMC Article
  5. SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling. Ohta S, et al. Dev Biol, 2016 Dec 1. PMID 27720745, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing.
    Title: SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling.
  2. mutation has a destabilizing effect on GLI3R uncovering an unappreciated mechanism by which HOXD13 determines the patterning of the limb.
    Title: An N-terminal G11A mutation in HOXD13 causes synpolydactyly and interferes with Gli3R function during limb pre-patterning.
  3. Results indicate that the Smo-induced Galpha(i) activity plays an insignificant role in the regulation of Gli3 processing and Shh-regulated neural tube patterning.
    Title: The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcriptional activator GLI3
Names
GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)
GLI3 full length protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271903.3 → NP_001258832.2  transcriptional activator GLI3 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    UniProtKB/TrEMBL
    A0A8V0Y2D1
    Related
    ENSGALP00010010306.1, ENSGALT00010018756.1
    Conserved Domains (2) summary
    COG5189
    Location:544 → 634
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550 → 572
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001398310.1 → NP_001385239.1  transcriptional activator GLI3 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    UniProtKB/TrEMBL
    A0A8V0Y2D1
    Conserved Domains (2) summary
    COG5189
    Location:544 → 634
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550 → 572
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001398311.1 → NP_001385240.1  transcriptional activator GLI3 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    Conserved Domains (2) summary
    COG5189
    Location:543 → 633
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:549 → 571
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001398312.1 → NP_001385241.1  transcriptional activator GLI3 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    Related
    ENSGALP00010010308.1, ENSGALT00010018758.1
    Conserved Domains (2) summary
    COG5189
    Location:485 → 575
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:491 → 513
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    50701998..50913787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015281558.4 → XP_015137044.2  transcriptional activator GLI3 isoform X2

    UniProtKB/Swiss-Prot
    Q9IA31
    UniProtKB/TrEMBL
    A0A8V0Y2D1
    Conserved Domains (2) summary
    COG5189
    Location:544 → 634
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550 → 572
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_046923906.1 → XP_046779862.1  transcriptional activator GLI3 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    50756375..50968180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911343.1 → XP_046767299.1  transcriptional activator GLI3 isoform X2

  2. XM_046911342.1 → XP_046767298.1  transcriptional activator GLI3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9IA31.1 GenPept UniProtKB/Swiss-Prot:Q9IA31

Gene LinkOut

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