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CDK6 cyclin dependent kinase 6 [ Gallus gallus (chicken) ]

Gene ID: 420558, updated on 5-Mar-2024

Summary

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Symbol
CDK6provided by CGNC
Full Name
cyclin dependent kinase 6provided by CGNC
Primary source
CGNC:51286
See related
Ensembl:ENSGALG00010005004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (22606846..22740743, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (22637730..22771595, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 1 Neighboring gene family with sequence similarity 133 member B Neighboring gene microRNA 1650 Neighboring gene uncharacterized LOC107052572 Neighboring gene uncharacterized LOC112531971 Neighboring gene sterile alpha motif domain containing 9 like Neighboring gene HEPACAM family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Retinoic acid promotes proliferation of chicken primordial germ cells via activation of PI3K/Akt-mediated NF-κB signalling cascade. Yu M, et al. Cell Biol Int, 2012 Aug 1. PMID 22548360
  2. Ginsenosides promote proliferation of granulosa cells from chicken prehierarchical follicles through PKC activation and up-regulated cyclin gene expression. Tan TQ, et al. Cell Biol Int, 2010 Jul. PMID 20402666
  3. TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. Ayala YM, et al. Proc Natl Acad Sci U S A, 2008 Mar 11. PMID 18305152, Free PMC Article
  4. An expressed sequence tag database of T-cell-enriched activated chicken splenocytes: sequence analysis of 5251 clones. Tirunagaru VG, et al. Genomics, 2000 Jun 1. PMID 10860659
  5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell dedifferentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 6
Names
cell division protein kinase 6
NP_001007893.1
NP_001384302.1
NP_001384303.1
NP_001384304.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007892.4 → NP_001007893.1  cyclin-dependent kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_001007893.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    Q90771
    Conserved Domains (1) summary
    cd07862
    Location:11 → 300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

  2. NM_001397373.1 → NP_001384302.1  cyclin-dependent kinase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    Q90771
    Related
    ENSGALP00010006583.1, ENSGALT00010011760.1
    Conserved Domains (1) summary
    cd07862
    Location:11 → 300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

  3. NM_001397374.1 → NP_001384303.1  cyclin-dependent kinase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    Q90771
    Conserved Domains (1) summary
    cd07862
    Location:11 → 300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

  4. NM_001397375.1 → NP_001384304.1  cyclin-dependent kinase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    A0A8V0XIR1
    Related
    ENSGALP00010006581.1, ENSGALT00010011757.1
    Conserved Domains (1) summary
    cl21453
    Location:11 → 283
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22606846..22740743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22637730..22771595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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