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STAT3 signal transducer and activator of transcription 3 [ Gallus gallus (chicken) ]

Gene ID: 420027, updated on 11-Apr-2024

Summary

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Symbol
STAT3provided by CGNC
Full Name
signal transducer and activator of transcription 3provided by CGNC
Primary source
CGNC:2374
See related
Ensembl:ENSGALG00010026098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
25
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 27 NC_052558.1 (4895063..4910486, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 27 NC_052599.1 (6057127..6072551, complement)

Chromosome 27 - NC_052558.1Genomic Context describing neighboring genes Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5A Neighboring gene microRNA mir-12257 Neighboring gene polymerase I and transcript release factor Neighboring gene ATPase H+ transporting V0 subunit a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Avian blood induced intranuclear translocation of STAT3 via the chicken leptin receptor. Ohkubo T, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Aug. PMID 24858374
  2. STAT3α interacts with nuclear GSK3beta and cytoplasmic RISK pathway and stabilizes rhythm in the anoxic-reoxygenated embryonic heart. Pedretti S, et al. Basic Res Cardiol, 2011 May. PMID 21279516
  3. JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells. Zhang Y, et al. In Vitro Cell Dev Biol Anim, 2017 Sep. PMID 28597334
  4. Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Haynes T, et al. Nat Commun, 2013. PMID 23942241, Free PMC Article
  5. In ovo leptin administration inhibits chorioallantoic membrane angiogenesis in female chicken embryos through the STAT3-mediated vascular endothelial growth factor (VEGF) pathway. Su L, et al. Domest Anim Endocrinol, 2012 Jul. PMID 22417645

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway.
    Title: UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway.
  2. these results suggest that MDV disables the ATR-Chk1 pathway through STAT3 activation to benefit its replication.
    Title: Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3.
  3. our results suggested that JAK-STAT effectively promoted the formation of primordial germ cells in the genital ridge during early embryogenesis in vivo and played a positive role in the regulation of embryonic stem cells to spermatogonial stem cells differentiation in vitro, with JAK2 and STAT3 functioning as pivotal factors for intracellular signal transduction
    Title: JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells.
  4. It is a gene related to signal transduction.
    Title: Effect of chicken leptin recptor short hairpin RNA on expression of JAK2, STAT3, SOCS3 and CPT1 genes in chicken preadipocytes.
  5. Avian blood contains a leptin-like molecule that specifically binds to leptin receptor, suggesting that the leptin system is conserved across all vertebrate classes.
    Title: Avian blood induced intranuclear translocation of STAT3 via the chicken leptin receptor.
  6. C3a induces retina regeneration via STAT3 activation, which activates the injury- and inflammation-responsive factors, IL-6, IL-8 and TNF-alpha and sets forth regulation of Wnt2b, Six3 and Sox2, genes associated with retina stem and progenitor cells.
    Title: Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
  7. These data suggest that in ovo leptin administration affects angiogenesis and embryo growth in female chicken embryos, probably through STAT3-mediated VEGF/nitric oxide pathways.
    Title: In ovo leptin administration inhibits chorioallantoic membrane angiogenesis in female chicken embryos through the STAT3-mediated vascular endothelial growth factor (VEGF) pathway.
  8. STAT3 could play in the protection of cardiovascular function in a developing organism
    Title: STAT3α interacts with nuclear GSK3beta and cytoplasmic RISK pathway and stabilizes rhythm in the anoxic-reoxygenated embryonic heart.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 3
Names
signal transducer and activator of transcription 3 (acute-phase response factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030931.4 → NP_001026102.2  signal transducer and activator of transcription 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000365
    UniProtKB/Swiss-Prot
    Q5F331, Q6DV79
    UniProtKB/TrEMBL
    A0A8V1AAG1
    Related
    ENSGALP00010039253.1, ENSGALT00010063595.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 716
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  2. NM_001398323.1 → NP_001385252.1  signal transducer and activator of transcription 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000365
    UniProtKB/Swiss-Prot
    Q5F331, Q6DV79
    Related
    ENSGALP00010039261.1, ENSGALT00010063606.1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 716
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  3. NM_001398324.1 → NP_001385253.1  signal transducer and activator of transcription 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000365
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

  4. NM_001398325.1 → NP_001385254.1  signal transducer and activator of transcription 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000365
    Conserved Domains (4) summary
    cd10374
    Location:554 → 715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052558.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4895063..4910486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040653164.2 → XP_040509098.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5F331, Q6DV79
    UniProtKB/TrEMBL
    A0A8V1AAG1
    Conserved Domains (4) summary
    cd10374
    Location:554 → 716
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2 → 120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139 → 318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321 → 484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052599.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6057127..6072551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046933364.1 → XP_046789320.1  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5F331, Q6DV79
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DV79.2 GenPept UniProtKB/Swiss-Prot:Q6DV79

Gene LinkOut

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