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BCO2 beta-carotene oxygenase 2 [ Gallus gallus (chicken) ]

Gene ID: 419792, updated on 3-Apr-2024

Summary

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Symbol
BCO2provided by CGNC
Full Name
beta-carotene oxygenase 2provided by CGNC
Primary source
CGNC:5953
See related
Ensembl:ENSGALG00010025042
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BCDO2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (6166113..6186951, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (6126866..6147725, complement)

Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene PLET1 homolog Neighboring gene 6-pyruvoyltetrahydropterin synthase Neighboring gene testis expressed 12 Neighboring gene interleukin 18 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene C11orf57 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic diversity of chicken breeds from Jiangxi, assessed with BCDO2 and the complete mitochondrial DNA D-loop region. Gao YS, et al. PLoS One, 2017. PMID 28257510, Free PMC Article
  2. Substrate Specificity of Purified Recombinant Chicken β-Carotene 9',10'-Oxygenase (BCO2). Dela Seña C, et al. J Biol Chem, 2016 Jul 8. PMID 27143479, Free PMC Article
  3. Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken. Eriksson J, et al. PLoS Genet, 2008 Feb 29. PMID 18454198, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There were five SNPs that defined two haplotypes, W and Y in BCDO2. Four breeds had one haplotype and three breeds had two. We conclude that Jiangxi native chicken breeds have relatively low genetic diversity and likely share four common maternal lineages from two different maternal ancestors of junglefowl
    Title: The genetic diversity of chicken breeds from Jiangxi, assessed with BCDO2 and the complete mitochondrial DNA D-loop region.
  2. Like BCO1, purified recombinant chicken BCO2 catalyzes the oxidative cleavage of the provitamin A carotenoids beta-carotene, alpha-carotene, and beta-cryptoxanthin.
    Title: Substrate Specificity of Purified Recombinant Chicken β-Carotene 9',10'-Oxygenase (BCO2).
  3. yellow skin is caused by one or more cis-acting and tissue-specific regulatory mutation(s) that inhibit expression of BCDO2 (beta-carotene dioxygenase 2) in skin
    Title: Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-carotene 15,15'-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carotenoid dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carotene catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinal metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta,beta-carotene 9',10'-oxygenase
Names
beta-carotene dioxygenase 2
XP_004948199.2
XP_040508163.1
XP_040508165.1
XP_040508166.1
XP_040546302.1
XP_040546303.1
XP_040546304.1
XP_040546305.1
XP_040546306.1
XP_046759776.1
XP_046759777.1
XP_046788408.1
XP_046788409.1
XP_417929.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    6166113..6186951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_417929.8 → XP_417929.3  beta,beta-carotene 9',10'-oxygenase isoform X3

    UniProtKB/TrEMBL
    A0A8V1A3N9, A0A8V1A8Y3
    Related
    ENSGALP00010037834.1, ENSGALT00010061157.1
    Conserved Domains (1) summary
    cl10080
    Location:76 → 579
    RPE65; Retinal pigment epithelial membrane protein

  2. XM_040652231.2 → XP_040508165.1  beta,beta-carotene 9',10'-oxygenase isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZW65, A0A8V1A3Q3
    Related
    ENSGALP00010037832.1, ENSGALT00010061153.1
    Conserved Domains (1) summary
    cl10080
    Location:45 → 548
    RPE65; Retinal pigment epithelial membrane protein

  3. XM_004948142.5 → XP_004948199.2  beta,beta-carotene 9',10'-oxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZW65, A0A8V1A3Q8
    Related
    ENSGALP00010037837.1, ENSGALT00010061162.1
    Conserved Domains (1) summary
    cl10080
    Location:107 → 610
    RPE65; Retinal pigment epithelial membrane protein

  4. XM_040652232.2 → XP_040508166.1  beta,beta-carotene 9',10'-oxygenase isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZW65, A0A8V1A8X8
    Related
    ENSGALP00010037829.1, ENSGALT00010061148.1
    Conserved Domains (1) summary
    cl10080
    Location:42 → 545
    RPE65; Retinal pigment epithelial membrane protein

  5. XM_040652229.2 → XP_040508163.1  beta,beta-carotene 9',10'-oxygenase isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZW65
    Conserved Domains (1) summary
    cl10080
    Location:73 → 576
    RPE65; Retinal pigment epithelial membrane protein

  6. XM_046903821.1 → XP_046759777.1  beta,beta-carotene 9',10'-oxygenase isoform X5

  7. XM_046903820.1 → XP_046759776.1  beta,beta-carotene 9',10'-oxygenase isoform X2

    UniProtKB/TrEMBL
    A0A8V1A1E0
    Related
    ENSGALP00010037830.1, ENSGALT00010061149.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6126866..6147725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040690369.2 → XP_040546303.1  beta,beta-carotene 9',10'-oxygenase isoform X3

    UniProtKB/TrEMBL
    A0A8V1A3N9, A0A8V1A8Y3
    Conserved Domains (1) summary
    cl10080
    Location:76 → 579
    RPE65; Retinal pigment epithelial membrane protein

  2. XM_040690371.2 → XP_040546305.1  beta,beta-carotene 9',10'-oxygenase isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZW65, A0A8V1A3Q3
    Conserved Domains (1) summary
    cl10080
    Location:45 → 548
    RPE65; Retinal pigment epithelial membrane protein

  3. XM_040690368.2 → XP_040546302.1  beta,beta-carotene 9',10'-oxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZW65, A0A8V1A3Q8
    Conserved Domains (1) summary
    cl10080
    Location:107 → 610
    RPE65; Retinal pigment epithelial membrane protein

  4. XM_040690372.2 → XP_040546306.1  beta,beta-carotene 9',10'-oxygenase isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZW65, A0A8V1A8X8
    Conserved Domains (1) summary
    cl10080
    Location:42 → 545
    RPE65; Retinal pigment epithelial membrane protein

  5. XM_040690370.2 → XP_040546304.1  beta,beta-carotene 9',10'-oxygenase isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZW65
    Conserved Domains (1) summary
    cl10080
    Location:73 → 576
    RPE65; Retinal pigment epithelial membrane protein

  6. XM_046932453.1 → XP_046788409.1  beta,beta-carotene 9',10'-oxygenase isoform X5

  7. XM_046932452.1 → XP_046788408.1  beta,beta-carotene 9',10'-oxygenase isoform X2

    UniProtKB/TrEMBL
    A0A8V1A1E0
Nucleotide Protein
Heading Accession and Version

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