SLC9A1 solute carrier family 9 member A1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SLC9A1provided by CGNC
Full Name: solute carrier family 9 member A1provided by CGNC
Primary source: CGNC:615
See related: Ensembl:ENSGALG00010016793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	23	NC_052554.1 (2237984..2256836, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	23	NC_052595.1 (2006938..2025749, complement)

Chromosome 23 - NC_052554.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene editing of the NHE1 gene resulted in chickens resistant to the avian leukosis virus.
Title: Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus.
findings demonstrate that extracellular loop 1 is critical for receptor function, with residues 28 to 39 constituting the minimal functional domain responsible for NHE1 binding of subgroup J avian leukosis virus (ALV-J) gp85 and efficiently mediating ALV-J cell entry
Title: Residues 28 to 39 of the Extracellular Loop 1 of Chicken Na(+)/H(+) Exchanger Type I Mediate Cell Binding and Entry of Subgroup J Avian Leukosis Virus.
studied the natural polymorphisms of NHE1 in wild ducks and geese because of recent reports on ALV-J positivity in feral
Title: Genetic Diversity of NHE1, Receptor for Subgroup J Avian Leukosis Virus, in Domestic Chicken and Wild Anseriform Species.
NHE1 protein is the receptor of ALV-J infection but also play an important role in tumor development.
Title: [The relationship of virus load, receptor expression and tumor spectrum in layer chickens infected by ALV-J].
Authors describe the functional importance of W38 for virus entry and conclude that natural polymorphisms in NHE1 can be a source of host resistance to subgroup J avian leukosis virus.
Title: Nonconserved tryptophan 38 of the cell surface receptor for subgroup J avian leukosis virus discriminates sensitive from resistant avian species.
NHE1 mRNA was detected in all chicken tissues examined, protein expression levels varied widely among tissues and did not always correlate with mRNA expression.
Title: Na+/H+ exchanger 1 gene expression in tissues of yellow chicken.
Calcineurin homologous protein plays an essential role in stabilizing NHE-1 (Na+/K+ exhanger isoform 1).
Title: Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na+/H+ exchanger isoform-1 protein.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sodium/hydrogen exchanger 1

Names: solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044643.2 → NP_001038108.1 sodium/hydrogen exchanger 1 precursor

See identical proteins and their annotated locations for NP_001038108.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000339

UniProtKB/TrEMBL

A0A1D5PZW7, M4M8W5, Q1PS52

Related

ENSGALP00010023522.1, ENSGALT00010040517.1

Conserved Domains (3) summary

TIGR00840
Location:87 → 652

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:97 → 495

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:594 → 693

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2237984..2256836 complement

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GenBank, FASTA, Sequence Viewer (Graphics)