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DFFA DNA fragmentation factor subunit alpha [ Gallus gallus (chicken) ]

Gene ID: 419451, updated on 5-Mar-2024

Summary

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Symbol
DFFAprovided by CGNC
Full Name
DNA fragmentation factor subunit alphaprovided by CGNC
Primary source
CGNC:2032
See related
Ensembl:ENSGALG00010016751
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (3732150..3735787, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (3765453..3768969, complement)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene phosphogluconate dehydrogenase Neighboring gene centromere protein S Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene uncharacterized LOC124417347 Neighboring gene castor zinc finger 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module. Samejima K, et al. J Biol Chem, 2014 Nov 7. PMID 25248749, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rapid ICAD depletion is sufficient to activate CAD and induce cell death in DT40 and yeast cells
    Title: Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA fragmentation factor subunit alpha
Names
DNA fragmentation factor, 45kDa, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3732150..3735787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_417610.8 → XP_417610.2  DNA fragmentation factor subunit alpha

    UniProtKB/TrEMBL
    A0A8V0YXQ9
    Related
    ENSGALP00010023422.1, ENSGALT00010040376.1
    Conserved Domains (1) summary
    cl02541
    Location:4 → 83
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3765453..3768969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040689163.2 → XP_040545097.1  DNA fragmentation factor subunit alpha

    UniProtKB/TrEMBL
    A0A8V0YXQ9
    Conserved Domains (1) summary
    cl02541
    Location:4 → 83
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
Nucleotide Protein
Heading Accession and Version

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