HES5A hes family bHLH transcription factor 5A [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: HES5Aprovided by CGNC
Official Full Name: hes family bHLH transcription factor 5Aprovided by CGNC
Primary source: CGNC:773
See related: Ensembl:ENSGALG00010019724
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HES5
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (1425599..1427012)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (1457077..1458490)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage.
Title: Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation.
results indicate that Hes5 is regulated by Engrailed and is responsible for rostral identity of mesencephalon by repressing ephrinA2
Title: Possible role of Hes5 for the rostrocaudal polarity formation of the tectum.
hes6-2 represses transcription of the hes5 genes, thus functioning as a negative regulator of Notch signaling. Conversely, hes6-2 may be repressed by hes5 activity.
Title: A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor HES-5

Names: hairy and enhancer of split 5; hes family bHLH transcription factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012695.2 → NP_001012713.1 transcription factor HES-5

See identical proteins and their annotated locations for NP_001012713.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000329

UniProtKB/TrEMBL

Q5D212

Related

ENSGALP00010028188.1, ENSGALT00010047620.1

Conserved Domains (2) summary

cd00083
Location:14 → 71

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cl02638
Location:84 → 120

Hairy_orange; Hairy Orange