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ITCH itchy E3 ubiquitin protein ligase [ Gallus gallus (chicken) ]

Gene ID: 419145, updated on 3-Apr-2024

Summary

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Symbol
ITCHprovided by CGNC
Full Name
itchy E3 ubiquitin protein ligaseprovided by CGNC
Primary source
CGNC:1384
See related
Ensembl:ENSGALG00010024723
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (1764094..1831397, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (1558313..1631200, complement)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene dynein light chain roadblock-type 1 Neighboring gene protein MANBAL-like Neighboring gene mannosidase, beta A, lysosomal-like 13 Neighboring gene U1 spliceosomal RNA Neighboring gene adenosylhomocysteinase Neighboring gene agouti signaling protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein K29-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Itchy homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1764094..1831397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040650890.2 → XP_040506824.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Related
    ENSGALP00010037118.1, ENSGALT00010060359.1
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  2. XM_040650891.2 → XP_040506825.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZZG2
    Related
    ENSGALP00010037108.1, ENSGALT00010060349.1
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:303 → 335
    WW; Domain with 2 conserved Trp (W) residues
    COG5021
    Location:335 → 713
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1558313..1631200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040688410.2 → XP_040544344.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  2. XM_040688404.2 → XP_040544338.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  3. XM_040688417.2 → XP_040544351.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  4. XM_040688414.2 → XP_040544348.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  5. XM_040688416.2 → XP_040544350.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  6. XM_040688413.2 → XP_040544347.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  7. XM_040688412.2 → XP_040544346.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  8. XM_040688405.2 → XP_040544339.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  9. XM_046931083.1 → XP_046787039.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

  10. XM_046931082.1 → XP_046787038.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

  11. XM_040688415.2 → XP_040544349.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  12. XM_040688409.2 → XP_040544343.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  13. XM_040688406.2 → XP_040544340.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  14. XM_040688403.2 → XP_040544337.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  15. XM_040688402.2 → XP_040544336.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZZH3
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:335 → 878
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:304 → 333
    WW; WW domain

  16. XM_040688418.2 → XP_040544352.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZZG2
    Conserved Domains (3) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:303 → 335
    WW; Domain with 2 conserved Trp (W) residues
    COG5021
    Location:335 → 713
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
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