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DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 [ Homo sapiens (human) ]

Gene ID: 4189, updated on 5-Mar-2024

Summary

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Official Symbol
DNAJB9provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B9provided by HGNC
Primary source
HGNC:HGNC:6968
See related
Ensembl:ENSG00000128590 MIM:602634; AllianceGenome:HGNC:6968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDG1; ERdj4; MDG-1; MST049; MSTP049
Summary
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in thyroid (RPKM 55.6), adrenal (RPKM 35.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7q31.1; 14q24.2-q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (108569874..108574850)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (109894482..109899458)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (108210318..108215294)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene patatin like phospholipase domain containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26503 Neighboring gene uncharacterized LOC124901722 Neighboring gene THAP domain containing 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:108209746-108210473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:108219440-108219950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:108219951-108220459 Neighboring gene MPRA-validated peak6685 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:108233899-108234540 Neighboring gene uncharacterized LOC105375448 Neighboring gene sorbitol dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients. Said SM, et al. Kidney Int, 2020 Aug. PMID 32622524
  2. Clinicopathological characteristics and outcome of patients with fibrillary glomerulonephritis: DNAJB9 is a valuable histologic marker. Liang S, et al. J Nephrol, 2021 Jun. PMID 32557205
  3. Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity. Sun F, et al. Cell Rep, 2020 Feb 11. PMID 32049014
  4. New developments in the diagnosis of fibrillary glomerulonephritis. Nasr SH, et al. Kidney Int, 2019 Sep. PMID 31227146
  5. Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients. Nasr SH, et al. Kidney Int, 2019 May. PMID 31010480

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells.
    Title: Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells.
  2. DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1.
    Title: DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1.
  3. DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients.
    Title: DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients.
  4. Clinicopathological characteristics and outcome of patients with fibrillary glomerulonephritis: DNAJB9 is a valuable histologic marker.
    Title: Clinicopathological characteristics and outcome of patients with fibrillary glomerulonephritis: DNAJB9 is a valuable histologic marker.
  5. Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity.
    Title: Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity.
  6. Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia.
    Title: Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia.
  7. New developments in the diagnosis of fibrillary glomerulonephritis.
    Title: New developments in the diagnosis of fibrillary glomerulonephritis.
  8. Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue DeltaF508-CFTR.
    Title: Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR.
  9. these observations support a competition model whereby waning ER stress passively partitions ERdj4 and BiP to IRE1(LD) to initiate active repression of UPR signalling.
    Title: Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.
  10. Study detected a 4-fold higher abundance of serum DNAJB9 in fibrillary glomerulonephritis (FGN) patients when compared to controls, including patients with other glomerular diseases. Serum DNAJB9 levels were also negatively associated with estimated glomerular filtration rate in patients with FGN.
    Title: Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564F1862

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of IRE1-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 9
Names
DnaJ (Hsp40) homolog, subfamily B, member 9
ER-resident protein ERdj4
endoplasmic reticulum DNA J domain-containing protein 4
endoplasmic reticulum DnaJ homolog 4
microvascular endothelial differentiation gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012328.3 → NP_036460.1  dnaJ homolog subfamily B member 9 precursor

    See identical proteins and their annotated locations for NP_036460.1

    Status: REVIEWED

    Source sequence(s)
    AB026908, DA202575
    Consensus CDS
    CCDS5752.1
    UniProtKB/Swiss-Prot
    Q9UBS3
    UniProtKB/TrEMBL
    Q6FIF1
    Related
    ENSP00000249356.3, ENST00000249356.4
    Conserved Domains (1) summary
    cl28246
    Location:26 → 136
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    108569874..108574850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    109894482..109899458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UBS3.1 GenPept UniProtKB/Swiss-Prot:Q9UBS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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