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CBLB Cbl proto-oncogene B [ Gallus gallus (chicken) ]

Gene ID: 418406, updated on 5-Mar-2024

Summary

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Symbol
CBLBprovided by CGNC
Full Name
Cbl proto-oncogene Bprovided by CGNC
Primary source
CGNC:11434
See related
Ensembl:ENSGALG00010005166
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (86890885..87014636, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (86941229..87064811, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107753 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC101751371 Neighboring gene uncharacterized LOC112530378 Neighboring gene BBX, HMG-box containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B
XP_004938335.1
XP_040514069.1
XP_040514070.1
XP_040514071.1
XP_040514072.1
XP_040561305.1
XP_040561307.1
XP_416621.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    86890885..87014636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004938278.5 → XP_004938335.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A8V0XF80
    Related
    ENSGALP00010006794.1, ENSGALT00010012182.1
    Conserved Domains (6) summary
    cd09920
    Location:293 → 389
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:400 → 578
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:929 → 969
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:399 → 464
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:89 → 209
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:216 → 299
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_416621.8 → XP_416621.3  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    F1NL77
    Related
    ENSGALP00010006793.1, ENSGALT00010012180.1
    Conserved Domains (6) summary
    cd09920
    Location:293 → 389
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:400 → 578
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:973 → 1013
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:399 → 464
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:89 → 209
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:216 → 299
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. XM_040705373.2 → XP_040561307.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:241 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:348 → 526
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:921 → 961
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:347 → 412
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  4. XM_040705371.2 → XP_040561305.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:241 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:348 → 526
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:921 → 961
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:347 → 412
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    86941229..87064811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040658136.2 → XP_040514070.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A8V0XF80
    Conserved Domains (6) summary
    cd09920
    Location:293 → 389
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:400 → 578
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:929 → 969
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:399 → 464
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:89 → 209
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:216 → 299
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_040658135.2 → XP_040514069.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    F1NL77
    Conserved Domains (6) summary
    cd09920
    Location:293 → 389
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:400 → 578
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:973 → 1013
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:399 → 464
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:89 → 209
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:216 → 299
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. XM_040658138.2 → XP_040514072.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:241 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:348 → 526
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:921 → 961
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:347 → 412
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  4. XM_040658137.2 → XP_040514071.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    Conserved Domains (4) summary
    cd09920
    Location:241 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    COG5243
    Location:348 → 526
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd14392
    Location:921 → 961
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:347 → 412
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
Nucleotide Protein
Heading Accession and Version

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