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EPS8 epidermal growth factor receptor pathway substrate 8 [ Gallus gallus (chicken) ]

Gene ID: 418174, updated on 3-Apr-2024

Summary

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Symbol
EPS8provided by CGNC
Full Name
epidermal growth factor receptor pathway substrate 8provided by CGNC
Primary source
CGNC:9898
See related
Ensembl:ENSGALG00010012768
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
28
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (62993338..63124573, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (63313467..63444278, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene RAS like estrogen regulated growth inhibitor Neighboring gene protein tyrosine phosphatase, receptor type O Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC121108252 Neighboring gene uncharacterized LOC107054199 Neighboring gene serine/threonine kinase receptor associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    62993338..63124573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040655696.2 → XP_040511630.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YFU5
    Conserved Domains (3) summary
    cd09540
    Location:693 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:503 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_416405.8 → XP_416405.4  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Related
    ENSGALP00010017771.1, ENSGALT00010030652.1
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_040655645.2 → XP_040511579.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Related
    ENSGALP00010017786.1, ENSGALT00010030673.1
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_004937964.5 → XP_004938021.2  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YFU5
    Conserved Domains (3) summary
    cd09540
    Location:693 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:503 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_004937962.5 → XP_004938019.2  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Related
    ENSGALP00010017765.1, ENSGALT00010030630.1
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_040655688.2 → XP_040511622.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YFU5
    Related
    ENSGALP00010017749.1, ENSGALT00010030593.1
    Conserved Domains (3) summary
    cd09540
    Location:693 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:503 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_004937963.5 → XP_004938020.2  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Related
    ENSGALP00010017754.1, ENSGALT00010030604.1
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  8. XM_046904964.1 → XP_046760920.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  9. XM_040655647.2 → XP_040511581.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  10. XM_046904968.1 → XP_046760924.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  11. XM_046904971.1 → XP_046760927.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  12. XM_046904976.1 → XP_046760932.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  13. XM_015292046.4 → XP_015147532.2  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  14. XM_040655679.2 → XP_040511613.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  15. XM_040655671.2 → XP_040511605.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    63313467..63444278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040658941.2 → XP_040514875.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YFU5
    Conserved Domains (3) summary
    cd09540
    Location:693 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:503 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_040658938.2 → XP_040514872.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_040658931.2 → XP_040514865.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_040658939.2 → XP_040514873.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YFU5
    Conserved Domains (3) summary
    cd09540
    Location:693 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:503 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_040658929.2 → XP_040514863.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_040658940.2 → XP_040514874.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YFU5
    Conserved Domains (3) summary
    cd09540
    Location:693 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:503 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_040658930.2 → XP_040514864.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  8. XM_046909816.1 → XP_046765772.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  9. XM_040658933.2 → XP_040514867.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  10. XM_046909817.1 → XP_046765773.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  11. XM_046909818.1 → XP_046765774.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  12. XM_046909819.1 → XP_046765775.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YIZ6

  13. XM_040658935.2 → XP_040514869.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  14. XM_040658937.2 → XP_040514871.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  15. XM_040658936.2 → XP_040514870.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAK0, A0A8V0YIZ6
    Conserved Domains (3) summary
    cd09540
    Location:726 → 790
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:536 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:61 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein Strain
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