U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CHRM2 cholinergic receptor muscarinic 2 [ Gallus gallus (chicken) ]

Gene ID: 418126, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Symbol
CHRM2provided by CGNC
Full Name
cholinergic receptor muscarinic 2provided by CGNC
Primary source
CGNC:9766
See related
Ensembl:ENSGALG00010013994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CM2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (57842999..57941748, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (58151253..58250395, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene pleiotrophin Neighboring gene uncharacterized LOC121107282 Neighboring gene uncharacterized LOC124417431 Neighboring gene microRNA 490 Neighboring gene uncharacterized LOC121106699 Neighboring gene uncharacterized LOC121106700 Neighboring gene myotrophin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Embryonic chick heart expresses multiple muscarinic acetylcholine receptor subtypes. Isolation and characterization of a gene encoding a novel m2 muscarinic acetylcholine receptor with high affinity for pirenzepine. Tietje KM, et al. J Biol Chem, 1991 Sep 15. PMID 1840593
  2. Transforming growth factor beta regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP. Park HJ, et al. J Biol Chem, 2006 Jul 21. PMID 16707504
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGFbeta regulation of M(2) muscarinic receptor expression is dependent on RhoA (M2 muscarinic receptor)
    Title: Transforming growth factor beta regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
muscarinic acetylcholine receptor M2
Names
m2 muscarinic acetylcholine receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030765.2 → NP_001025936.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001025936.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/Swiss-Prot
    P30372
    Related
    ENSGALP00010019790.1, ENSGALT00010033599.1
    Conserved Domains (1) summary
    cd15297
    Location:27 → 451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001397962.1 → NP_001384891.1  muscarinic acetylcholine receptor M2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/Swiss-Prot
    P30372
    Related
    ENSGALP00010019786.1, ENSGALT00010033586.1
    Conserved Domains (1) summary
    cd15297
    Location:27 → 451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    57842999..57941748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040697001.2 → XP_040552935.1  muscarinic acetylcholine receptor M2 isoform X1

    Conserved Domains (1) summary
    cd15297
    Location:27 → 451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_046939142.1 → XP_046795098.1  muscarinic acetylcholine receptor M2 isoform X1

  3. XM_046939146.1 → XP_046795102.1  muscarinic acetylcholine receptor M2 isoform X2

    UniProtKB/Swiss-Prot
    P30372
    Related
    ENSGALP00010019773.1, ENSGALT00010033550.1

  4. XM_040696994.2 → XP_040552928.1  muscarinic acetylcholine receptor M2 isoform X1

    Conserved Domains (1) summary
    cd15297
    Location:27 → 451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_046939143.1 → XP_046795099.1  muscarinic acetylcholine receptor M2 isoform X2

    UniProtKB/Swiss-Prot
    P30372
    Related
    ENSGALP00010019777.1, ENSGALT00010033559.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    58151253..58250395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046907534.1 → XP_046763490.1  muscarinic acetylcholine receptor M2 isoform X1

  2. XM_046907538.1 → XP_046763494.1  muscarinic acetylcholine receptor M2 isoform X2

  3. XM_046907536.1 → XP_046763492.1  muscarinic acetylcholine receptor M2 isoform X1

  4. XM_046907541.1 → XP_046763497.1  muscarinic acetylcholine receptor M2 isoform X2

  5. XM_046907535.1 → XP_046763491.1  muscarinic acetylcholine receptor M2 isoform X1

  6. XM_046907539.1 → XP_046763495.1  muscarinic acetylcholine receptor M2 isoform X2

  7. XM_046907540.1 → XP_046763496.1  muscarinic acetylcholine receptor M2 isoform X2

  8. XM_046907537.1 → XP_046763493.1  muscarinic acetylcholine receptor M2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30372.1 GenPept UniProtKB/Swiss-Prot:P30372

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.