APAF1 apoptotic peptidase activating factor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: APAF1provided by CGNC
Full Name: apoptotic peptidase activating factor 1provided by CGNC
Primary source: CGNC:8763
See related: Ensembl:ENSGALG00010010618
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (46763389..46790854)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (47060709..47088174)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-187-5p/apaf-1 axis was involved in oxidative stress-mediated apoptosis caused by ammonia via mitochondrial pathway in chicken livers.
Title: miR-187-5p/apaf-1 axis was involved in oxidative stress-mediated apoptosis caused by ammonia via mitochondrial pathway in chicken livers.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of apoptosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: apoptotic protease-activating factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

46763389..46790854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_416167.8 → XP_416167.4 apoptotic protease-activating factor 1 isoform X1

UniProtKB/TrEMBL

A0A8V0Y7E8

Related

ENSGALP00010014317.1, ENSGALT00010025275.1

Conserved Domains (3) summary

cd00200
Location:605 → 908

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd08323
Location:8 → 92

CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1

sd00039
Location:659 → 695

7WD40; WD40 repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

47060709..47088174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040662305.2 → XP_040518239.1 apoptotic protease-activating factor 1 isoform X1

UniProtKB/TrEMBL

A0A8V0Y7E8

Conserved Domains (3) summary

cd00200
Location:605 → 908

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd08323
Location:8 → 92

CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1

sd00039
Location:659 → 695

7WD40; WD40 repeat [structural motif]
XM_040662306.2 → XP_040518240.1 apoptotic protease-activating factor 1 isoform X2

UniProtKB/TrEMBL

A0A8V0Y7E8

Conserved Domains (4) summary

cd00200
Location:605 → 908

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd08323
Location:8 → 92

CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1

sd00039
Location:659 → 695

7WD40; WD40 repeat [structural motif]

cl29593
Location:962 → 1076

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_040662307.2 → XP_040518241.1 apoptotic protease-activating factor 1 isoform X3

Conserved Domains (4) summary

smart00320
Location:608 → 637

WD40; WD40 repeats

pfam00931
Location:129 → 373

NB-ARC; NB-ARC domain

pfam17908
Location:453 → 587

APAF1_C; APAF-1 helical domain

cl14633
Location:8 → 92

DD; Death Domain Superfamily of protein-protein interaction domains
XM_040662308.2 → XP_040518242.1 apoptotic protease-activating factor 1 isoform X4

Conserved Domains (3) summary

pfam00931
Location:129 → 373

NB-ARC; NB-ARC domain

pfam17908
Location:453 → 538

APAF1_C; APAF-1 helical domain

cl14633
Location:8 → 92

DD; Death Domain Superfamily of protein-protein interaction domains