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PRKCA protein kinase C alpha [ Gallus gallus (chicken) ]

Gene ID: 417430, updated on 3-Apr-2024

Summary

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Symbol
PRKCAprovided by CGNC
Full Name
protein kinase C alphaprovided by CGNC
Primary source
CGNC:50506
See related
Ensembl:ENSGALG00010029209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (7945750..8084827, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (7540629..7679608, complement)

Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107130 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene centrosomal protein 112 Neighboring gene apolipoprotein H Neighboring gene uncharacterized LOC107052245 Neighboring gene axin 2 Neighboring gene regulator of G-protein signaling 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase. Lee YA, et al. Mol Cells, 2007 Aug 31. PMID 17846494
  2. Reduced PKCalpha expression in pulmonary arterioles of broiler chickens is associated with early feed restriction. Pan JQ, et al. Res Vet Sci, 2008 Jun. PMID 17707446
  3. Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Guo D, et al. Mol Cell Neurosci, 2012 May. PMID 22521536, Free PMC Article
  4. Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. Tunsophon S, et al. Steroids, 2010 Apr. PMID 20079367
  5. Role of interleukin-6 in the control of DNA synthesis of hepatocytes: involvement of PKC, p44/42 MAPKs, and PPARdelta. Suh HN, et al. Cell Physiol Biochem, 2008. PMID 19088449

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKCalpha directly phosphorylates integrin-linked kinase on threonine-173 and -181 in vitro. Dominant negative PKCalpha disrupts RGC axon pathfinding at the optic chiasm.
    Title: Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.
  2. PKCalpha and PKCbeta are both involved in steroid-stimulated phosphate uptake.
    Title: Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake.
  3. IL-6 stimulates the proliferation of primary cultured chicken hepatocytes through PKC, p44/42 MAPKs, and PPARdelta pathways.
    Title: Role of interleukin-6 in the control of DNA synthesis of hepatocytes: involvement of PKC, p44/42 MAPKs, and PPARdelta.
  4. IL-6 stimulates the 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca(2+)/PKC and EGF receptor in primary cultured chicken hepatocytes.
    Title: Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes.
  5. Short time exposure to hypoxia increases DNA synthesis in primary cultured chicken hepatocytes through cooperation of Ca2+/PKC, p38 MAPK, p44/42 MAPKs, and PI3K/Akt pathways.
    Title: A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: Correlation between Ca(2+)/PKC/MAPKs and PI3K/Akt/mTOR.
  6. Early time feed restriction inhibits pulmonary vascular remodeling in broilers, which may be partly attributed to reduced PKCalpha expression in pulmonary arterioles.
    Title: Reduced PKCalpha expression in pulmonary arterioles of broiler chickens is associated with early feed restriction.
  7. p38 MAP kinase activities are required for chondrocyte redifferentiation in a model system of dedifferentiated chondrocytes
    Title: Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase.
  8. PKC and p38 MAP kinase activities are required for chondrocyte redifferentiation in a model system of dedifferentiated chondrocytes.
    Title: Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase.
  9. binding of annexin V to active PKCalpha stimulates apoptotic events in growth plate chondrocytes and binding of annexin V to beta5 integrin controls these interactions and ultimately apoptosis
    Title: Annexin V/beta5 integrin interactions regulate apoptosis of growth plate chondrocytes.
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Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C alpha type
NP_001012822.1
XP_004946286.1
XP_024997373.1
XP_040505434.1
XP_040505435.1
XP_040505436.1
XP_040505437.1
XP_046757994.1
XP_046757995.1
XP_046757996.1
XP_046757998.1
XP_046785380.1
XP_046785381.1
XP_046785382.1
XP_046785383.1
XP_046785384.1
XP_046785385.1
XP_046785386.1
XP_046785387.1
XP_046785388.1
XP_046785389.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012804.2 → NP_001012822.1  protein kinase C alpha type

    See identical proteins and their annotated locations for NP_001012822.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A0A8V1ABC9, Q5F3X1
    Related
    ENSGALP00010043281.1, ENSGALT00010070590.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:341 → 599
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05615
    Location:330 → 670
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:37 → 89
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7945750..8084827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040649503.2 → XP_040505437.1  protein kinase C alpha type isoform X6

    Conserved Domains (3) summary
    cd04026
    Location:30 → 160
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:209 → 549
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cl00040
    Location:1 → 26
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  2. XM_025141605.3 → XP_024997373.1  protein kinase C alpha type isoform X6

    Conserved Domains (3) summary
    cd04026
    Location:30 → 160
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:209 → 549
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cl00040
    Location:1 → 26
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  3. XM_046902039.1 → XP_046757995.1  protein kinase C alpha type isoform X4

  4. XM_046902038.1 → XP_046757994.1  protein kinase C alpha type isoform X4

  5. XM_046902042.1 → XP_046757998.1  protein kinase C alpha type isoform X6

  6. XM_046902040.1 → XP_046757996.1  protein kinase C alpha type isoform X6

  7. XM_004946229.5 → XP_004946286.1  protein kinase C alpha type isoform X3

    UniProtKB/TrEMBL
    A0A8V1ABC9, R4GHL2
    Related
    ENSGALP00010043283.1, ENSGALT00010070592.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:349 → 607
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05615
    Location:338 → 678
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:37 → 89
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  8. XM_040649501.2 → XP_040505435.1  protein kinase C alpha type isoform X2

    UniProtKB/TrEMBL
    A0A8V1ABC9, A0A8V1AMK5
    Related
    ENSGALP00010043282.1, ENSGALT00010070591.1
    Conserved Domains (3) summary
    cd04026
    Location:236 → 366
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00109
    Location:179 → 228
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd05615
    Location:407 → 747
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

  9. XM_040649500.2 → XP_040505434.1  protein kinase C alpha type isoform X1

    UniProtKB/TrEMBL
    A0A8V1ABC9
    Conserved Domains (3) summary
    cd04026
    Location:236 → 366
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00109
    Location:179 → 228
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd05615
    Location:415 → 755
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

  10. XM_040649502.2 → XP_040505436.1  protein kinase C alpha type isoform X5

    Conserved Domains (3) summary
    cd04026
    Location:236 → 366
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00109
    Location:179 → 228
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl21453
    Location:429 → 597
    PKc_like; Protein Kinases, catalytic domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7540629..7679608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929432.1 → XP_046785388.1  protein kinase C alpha type isoform X6

  2. XM_046929430.1 → XP_046785386.1  protein kinase C alpha type isoform X6

  3. XM_046929428.1 → XP_046785384.1  protein kinase C alpha type isoform X4

  4. XM_046929427.1 → XP_046785383.1  protein kinase C alpha type isoform X4

  5. XM_046929433.1 → XP_046785389.1  protein kinase C alpha type isoform X6

  6. XM_046929431.1 → XP_046785387.1  protein kinase C alpha type isoform X6

  7. XM_046929426.1 → XP_046785382.1  protein kinase C alpha type isoform X3

    UniProtKB/TrEMBL
    R4GHL2

  8. XM_046929425.1 → XP_046785381.1  protein kinase C alpha type isoform X2

  9. XM_046929424.1 → XP_046785380.1  protein kinase C alpha type isoform X1

  10. XM_046929429.1 → XP_046785385.1  protein kinase C alpha type isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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